Laboratory of Neuromuscular Pathology
We process and perform full diagnostic analysis of skeletal muscle and peripheral nerve specimens from adult and pediatric patients at this facility. We routinely accept and process specimens from the OHSU hospitals, other institutions and clinics in Oregon and from other states as express-mailed fresh tissue samples, and/or fixed samples for paraffin embedding and electron microscopy. Common diagnostic inquiries include inflammatory myopathies (polymyositis, dermatomyositis, inclusion body myositis), various dystrophies, metabolic myopathies (mitochondrial myopathy, acid maltase, myophosphorylase deficiency, and others), drug-induced myopathy (statin myopathy and others) and motor neuron diseases. For a complete and accurate evaluation of neuromuscular diseases, appropriately prepared and shipped fresh samples are critical. For handling fresh muscle and nerve biopsy specimens and shipping instructions please refer to our Protocols for Muscle and Nerve Biopsies. We have a comprehensive histochemistry panel for evaluation of neuromuscular diseases (1), and immunohistochemical panels for dystrophies (2) and inflammatory myopathies (3). In selected cases, we also perform ultrastructural analysis of muscle and peripheral nerve specimens at our electron microscope facility.