MISCELLANEOUS WORKING FORMULATION FOR NON-HODGKIN'S LYMPHOMAS A working formulation for non-Hodgkin's lymphoma for clinical use - January 1980. LOW GRADE LYMPHOMAS Small lymphocytic (well differentiated lymphocytic) Follicular, mixed small cleaved and large cell (nodular mixed lymphocytic-histiocytic) INTERMEDIATE GRADE LYMPHOMAS Follicular, large cell (nodular histiocytic) Diffuse, small cleaved cell (diffuse poorly differentiated lymphocytic) Diffuse, mixed, small and large cell Diffuse, large cell (diffuse histiocytic) HIGH GRADE LYMPHOMAS Diffuse, mixed, lymphocytic-histiocytic Diffuse large cell immunoblastic (diffuse, histiocytic) Lymphoblastic (lymphoblastic) Diffuse, small non-cleaved cell (Burkitt's and non-Burkitt's) Diffuse, undifferentiated, Burkitt's and non-Burkitt's MISCELLANEOUS Mycosis Fungoides/Sezary's Syndrome Unclassifiable ENDOMETRIAL DATING 16th Day Subnuclear cabuoles Pseudostratification Mitoses, glands and stroma 17th Day More or less orderly row of nuclei Cytoplasm above nuclei and subnuclear cauoles below Gland and stromal mitoses Very, very, very minimal secretion 18th Day Vacuoles above and below nuclei Improved linear arrangement of nuclei Gland mitoses rare Stromal mitoses rare Bubbles of secretion seen in luminal border 19th Day A few vacuoles remain in cell. Mainly active evacuation with intraluminal secretion No gland or stromal mitoses May look like day 16 but NO pseudostratification 20th Day Peak secretion with "ragged" luminal border Vacuoles are rare - all subnuclear vacuoles gone. Inspissation may be beginning 21st Day Abrupt onset of stromal edema Gland secretion prominent (inspissated) "Naked" stromal nuclei begin to appear 22nd Day Peak edema Marked appearance of "naked" stromal nuclei. Stromal cells small and dense filamentous cytoplasm Active secretion, but subsiding Rare stromal mitoses 23rd Day Prominent spiral arterioles Periarteriolar cuffing with *enlargement of stromal cell nuclei and cytoplasm. *(earliest predecidual change) Stromal mitoses Glands with secretory "exhaustion" - low columnar cells, luminal edges ragged 24th Day Definite predecidual cells around arterioles with early subepithelial changes Greater stromal mitoses Ragged cell borders, i.e. secretorily exhausted 25th Day Definite subcapsular predecidual Inspissated secretion noted to begin Early stromal infiltration with lymphocytes and occasional PMN's 26th Day Generalized decidual reaction - decidual islands in stroma Polymorphonuclear leukocytic invasion (lymphocytes may accompany or precede) 27th Day Solid sheet of decidual Marked leukocytic infiltrate. Polys prominent Cells may show secretory exhaustion or may show active secretion Beginning stromal clumping and fragmentation of glands Menstruating Disruption of capsular layer Stromal clumping Glandular break-up and hemorrhage Variable leukocytic infiltration Edema After 24 hours, metaplastic alterations on surface