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Marjorie Grafe, MD, PhD
Vice Chair, Education
Medical Director, Neuropathology
Program Director, Neuropathology Fellowship
Rank: Professor
Clinical Services: Neuropathology
Clinical Interests: Neuropathology
Research Interests: Perinatal and Adult Ischemic Brain Injury
Joint Appoinment: OHSU Anesthesiology & Perioperative Medicine (Research)
1976     BA, Stanford University, Stanford, CA,
1981     PhD, University of Florida, Gainesville, FL
1985     MD, Stanford University, Stanford, CA
1985 - 1989     Resident in Anatomic Pathology & Neuropathology, University of California, San Diego
1990     Anatomic Pathology & Neuropathology
Previous Position:
1997 - 2003    Professor, Department of Pathology - University of Texas Medical Branch at Galveston (UTMB)
1994 - 1997    Associate Professor, UTMB
1989 - 1994    Assistant Professor, University of California, San Diego
Selected References:
  • Qiu J, Grafe MR, Schmura SM, Glasgow JN, Kent TA, Rassin DK, Perez-Polo JR. Differential NF-B regulation of bcl-x gene expression in hippocampus and basal forebrain in response to hypoxia. J Neurosci Res 64:223-234, 2001.
  • Conroy BP, Grafe MR, Jenkins LW, Lin CY, DeWitt DS, Johnston WE. Histopathologic consequences of hyperglycemic cerebral ischemia during hypothermic cardiopulmonary bypass in pigs. Ann Thorac Surg 71:1325-1334, 2001.
  • Glasgow JN, Qiu J, Rassin D, Grafe M, Wood T, Perez-Polo JR. Transcriptional regulation of the BCL-X gene by NF-B is an element of hypoxic responses in the rat brain. Neurochemical Research 26:647-659, 2001.
  • Witlin AG, Li Z-Y, Wimalawansa SJ, Grady JJ, Grafe MR, Yallampalli C. Placental and fetal growth and development in late rat gestation is dependent on adrenomedullin. Biology of Reproduction 67:1025-1031, 2002.
  • Chu D, Qiu J, Grafe M, Fabian R, Kent TA, Rassin D, Nesic O, Werrbach-Perez K, Perez-Polo R. Delayed cell death signaling in traumatized central nervous system: hypoxia. Neurochemical Research. 27:97-106, 2002.
  • Hu X, Qiu J, Grafe MR, Rea HC, Rassin DK, Perez-Polo JR. Bcl-2 family members make different contributions to cell death in hypoxia and/or hyperoxia in rat cerebral cortex. Int J Devel Neurosci 21:371-377, 2003.
  • Witlin AG, Gangula PR, Wimalawansa SJ, Grafe M, Grady JJ, Yallampalli C. Adrenomedullin requires an intact nitric oxide system to function as an endogenous vasodilator in rat gestation. Hypertension in Pregnancy 22: 9-24, 2003.
  • Yaksh TL, Horais KA, Tozier N, Rathbun M, Richter P, Rossi S, Grafe M, Tong C, Meschter C, Cline JM, Eisenach J. Intrathecal ketorolac in dogs and rats. Toxicological Sciences 80:322-334, 2004.
  • Qiu J, Hu X, Nesic O, Grafe MR, Rassin DK, Wood TG, Perez-Polo JR. Effects of NF-B oligonucleotide "decoys" on gene expression in P7 rat hippocampus after hypoxia/ischemia. J Neurosci Research 77:108-118, 2004.
  • Linhart JM, Grafe MR, Saade GR, Velagaleti GV. Sonographic, pathologic and karyotypic findings in a rare case of placenta fenestrata. Fetal Diagnosis & Therapy 19:479-482, 2004.
  • Martin SS, Perez-Polo JR, Noppens KM, Grafe MR. Biphasic changes in the levels of poly(ADP-ribose) polymerase and caspase 3 in the immature brain following hypoxia-ischemia. Int J Devel Neurosci 23:673-686, 2005.
  • Kofler J, Otsuka T, Zhang Z, Noppens R, Grafe MR, Koh DW, Dawson VL, de Murcia JM, Hurn PD, Traystman RJ. Differential effect of PARP-2 deletion on brain injury after focal and global cerebral ischemia. J Cerebral Blood Flow Metab 26:135-41, 2006.
  • Allen JW, Mantyh PW, Horais K, Tozier N, Rogers SD, Ghilardi JR, Cizkova D, Grafe MR, Richter P, Lappi DA, Yaksh TL. Safety evaluation of intrathecal Substance P-Saporin, a targeted neurotoxin, in dogs. Toxicological Sciences, 91:286-98, 2006.

Last Updated: 02/17/2010