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Christopher Corless, MD, PhD
Vice Chair, Research
Director, Cancer Pathology Shared Resource
Chief, Surgical Pathology
Rank: Professor
Clinical Services: Surgical Pathology
Clinical Interests: Liver Transplant Pathology, Gastrointestinal Pathology, Genitourinary Pathology
Research Interests: Role of tyrosine kinase mutation in human malignancies Microarray analysis Corless research page: in identification of novel molecular targets and testing of new agents in the laboratory and in clinical trials. We are also focused on immunohistochemical and molecular testing to novel therapeutic targets, development of new assays for mutation detection.
 
Education:
1981    University of California, Berkeley - BA
1988    Washington University, St. Louis - MD, PhD

Training:
1988-93  Department of Pathology, Brigham and Womens Hospital, Boston

    Residency in Anatomic Pathology
    Fellowship in Gastrointestinal Pathology
    Fellowship in Gentourinary Pathology
Boards:
Anatomic Pathology
Previous Position:
1993-94   Department of Pathology, Brigham and Womens Hospital
                Instructor in Pathology, Harvard Medical School
Selected References:
  • Heinrich MC, Corless CL, Duensing A, McGreevey L, Chen C-J, Joseph N, Singer S, Griffith DJ, Haley A, Town A, Demetri G, Fletcher CDM, Fletcher JA. PDGFRA activating mutations in gastrointestinal stromal tumors. Science 299:708-710, 2003.
  • Heinrich MC, Corless CL, Demetri GD, Blanke CD, von Mehren M, Joensuu H, McGreevey LS, Chen C-J, Kiese B, Eisenberg B, Roberts PJ, Singer S, Fletcher CDM, Silberman S, Dimitrijevic S, Fletcher JA. Kinase mutations and imatinib mesylate response in patients with metastatic gastrointestinal stromal tumor. J Clin Onc 21:4342-4349, 2003.Corless CL, Fletcher JA, Heinrich MC. Biology of gastrointestinal stromal tumors. J Clin Oncol 22:3813-3825, 2004.
  • Heinrich MC, Corless CL, Blanke CD, Demetri, GD, Joensuu H, Roberts PJ, Eisenberg B, von Mehren M, Fletcher CDM, Sandau K, McDougall K, Ou WB, Chen C-J, Fletcher JA. Molecular correlates of imatinib resistance in gastrointestinal stromal tumors. J Clin Onc 24:4764-74, 2006.
  • Corless CL, Harrell P, Lacouture M, Bainbridge T, Le C, Gatter K, White C Jr, Granter S, Heinrich MC. Allele-Specific Polymerase Chain Reaction for the Imatinib-Resistant KIT D816V and D816F Mutations in Mastocytosis and Acute Myelogenous Leukemia. J Mol Diagn 8:604-12, 2006.
  • Schmidt JF, Derr V, Heinrich MC, Crum CP, Fletcher JA, Corless CL, Nosé V. BRAF mutations in malignant struma ovarii. Am J Surg Pathol 31:1337-1343, 2007.
  • Aubry M-C, Heinrich MC, Molina J, Lewis J, Yang P, Cassivi S, Corless CL. Primary adenoid cystic carcinoma of the lung: absence of KIT mutations. Cancer 110:2507-10, 2007.
  • Heinrich MC, Maki RG, Corless CL, Antonescu CR, Harlow A, Griffith D, Town A, McKinley A, Ou WB, Fletcher JA, Fletcher CD, Huang X, Cohen DP, Baum CM, Demetri GD. Primary and secondary kinase genotypes correlate with the biological and clinical activity of sunitinib in imatinib-resistant gastrointestinal stromal tumor. J Clin Oncol. 26(33):5352-9, 2008.
  • Liegl B, Kepten I, Le C, Demetri GD, Heinrich MC, Fletcher CDM, Corless CL, Fletcher JA. Substantial heterogeneity of kinase inhibitor resistance mechanisms in GIST. J Pathology 216(1):64-74, 2008.
  • Beadling C, Jacobson-Dunlop E, Hodi FS, Le C, Warrick A, Patterson J, Town A, Harlow A, Cruz F 3rd, Azar S, Rubin BP, Muller S, West R, Heinrich MC, Corless CL. KIT Gene mutations and copy number in melanoma subtypes. Clin Cancer Res. 14(21):6821-8, 2008.

Last Updated: 07/08/2009