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Donald Houghton, MD
Renal Pathologist
Rank: Professor
Clinical Services: Renal Pathology
Clinical Interests: Renal Pathology
Research Interests: Clinical & Experimental renal disease
1968     BS, University of Oregon, Eugene, Oregon
1972     MD, University of Oregon Medical School (now OHSU), Portland, Oregon
Anatomic Pathology

Postgraduate and Sabbatical Training:

1969 - 1972     Student Fellow in Anatomic Pathology, University of Oregon Medical School
1972 - 1973     Intern in Internal Medicine, University of Wisconsin, Madison, Wisconsin
1973 - 1975     Resident in Anatomic Pathology, University of Oregon Medical School
1981 - 1985     Fellow in Nephrology, Oregon Health Sciences University
1987 - 1988     Visiting Scientist, Diabetes Laboratory, Pathology Institute, Aarhus University, Aarhus, Denmark
Previous Position:
Selected References:
  • Houghton DC, Hartnett M, Campbell-Boswell M, Porter G, and Bennett W. A light and electron microscopic analysis of gentamicin nephrotoxicity in rats. Am J Path 82:589-612, 1976.
  • Bennett W, Gilbert D, Houghton DC, and Porter G. Gentamicin nephrotoxicity in man: Morphologic and pharmacologic features. West J Med 126:65, 1977.
  • Bennett WM, Bardana EJ, Houghton DC, and Striker GD. Silent renal involvement in systemic lupus erythematosus. Internat. Arch Allergy Appl Immunol 55:420-428, 1977.
  • Houghton DC, Plamp CE, DeFehr JM, Bennett WM, Porter GA, and Gilbert D. Gentamicin and tobramycin nephrotoxicity: A morphologic and functional comparison in the rat. Am J Path 93:137-152, 1978.
  • Parker RA, Bennett WM, Plamp CE, Houghton DC, Gilbert DN, and Porter GA. Resistance of female rats to gentamicin nephrotoxicity. Current Chemother 1:601-602, 1980.
  • Bennett WM, Pastore L, and Houghton DC. Fatal pulmonary bleomycin toxicity in CIS-platinum induced acute renal failure. Cancer Treatment Reports 64:921-924, 1980.
  • Bennett WM, Barry JM, and Houghton DC. Chronic tubulointerstitial nephritis from infectious mononucleosis. West J Med 133:248-249, 1980.
  • Bennett WM, Houghton DC, and Beals RC. Nephropathy of idiopathic multicentric osteolysis. Nephron 25:134-138, 1980.
  • Bennett WM, Bardana EJ, Norman DJ, and Houghton DC. Natural history of "silent" lupus nephritis. Am J Kidney Dis 1:359-363, 1982.
  • Houghton DC, Gilbert DN, and Bennett WM. Chronic experimental gentamicin nephrotoxicity: Continued tubular injury with preserved glomerular filtration function. Am J Path 123:183-194, 1986.
  • Houghton DC, English J, and Bennett WM. Chronic tubulointerstitial nephritis and renal insufficiency associated with long-term "sub-therapeutic" gentamicin. J Lab Clin Med 112:694-703, 1988.
  • Miyake JS, Fitterer S, Houghton DC. Renal biopsy case: Diagnosis and characterization of non-Hodgkin's lymphoma in a patient with acute renal failure. Am J Kidney Dis 16:262-263, 1990.
  • Bennett WM, Houghton DC, and Buss WC. Cyclosporine-induced renal dysfunction: Correlations between cellular events and whole kidney function. J Am Soc Nephrol 1:1212-1219, 1991.
  • Swan SK, Schnell S, Houghton DC, Barry JM, Bennett WM. Membranous nephropathy in renal allograft recipients. Clin Transplantation 5:90-93, 1991.
  • Guinee DG Jr, Van Zee B and Houghton DC. Clinically silent progressive renal tubulointerstitial disease during cisplatin chemotherapy. Cancer 71:4050-4054, 1993.
  • Wernick R, Smith DL, Houghton DC, Booth J, Runckel D, Johnson D, Phillips D, Kohnen P, Brown K and Gaboury C. Reliability of semiquantitative histologic scoring system for lupus nephritis. Ann Int Med 119:805-811, 1993.
  • Bonsib SM, Goeken JA, Fandel T and Houghton DC. Necrotizing medullary lesions in patients with ANCA-associated renal disease. Modern Pathol 7:181-185, 1994.
  • Andoh TF, Burdmann EA, Fransechini N, Houghton DC, and Bennett WM. Comparison of acute rapamycin nephrotoxicity with cyclosporine and FK506. Kidney Internat. 50:1110-1117, 1996.
  • Lande MB, Thomas GA and Houghton DC. Membranous nephropathy associated with chronic immune thrombocytopenia purpura in childhood. Am J Kidney Dis. 37:E40, 2001.
  • Bennett WM, Hansen KS, Houghton DC and McEvoy KM. Disseminated intravascular coagulation (DIC) in a kidney donor associated with transient recipient DIC. Am J Transplantation. 5:412-414, 2005.
  • Subramanya A, Houghton D and Watnik S. Steroid-responsive idiopathic glomerular capillary endotheliosis: case report and literature review. Am J Kidney Dis. 45:1090-1095, 2005.
  • Troxell ML, Dunlap JB, Mittalhankle A, Ishag M, Fan G, Huang JZ, Gatter K, Byrd DM, Webster D and Houghton DC: Rejection versus posttransplantation lymphoproliferative disorder in a renal transplant recipient. Am J Kidney Dis. 52:1174-1179, 2008.
  • Mackensen F, David F, Schwenger V, Smith LK, Rajalingam R, Levinson RD, Austin CR, Houghton D, Martin TM, Rosenbaum JT. HLA-DRB1*0102 is associated with TINU syndrome and bilateral, sudden-onset anterior uveitis but not with interstitial nephritis alone. Br J Ophthalmol, Nov 2010 [Epub ahead of print]
  • Houghton DC and Troxell ML: An abundance of IgG4+ plasma cells is not specific for IgG4-related tubulointerstitial nephritis. Mod Pathol. 24(11):1480-1487, 2011.
  • Kearney N, Podolak J, Matsumura L, Houghton D and Troxell M. Patterns of IgG subclass deposits in membranous glomerulonephritis in renal allografts. Transplant Proc, 43, 3743-3746 (2011)
  • Troxell ML, Houghton DC, Hawkey M, Batiuk TD and Bennett: Enteric oxalate nephropathy in the renal allograft: an under recognized complication of bariatric surgery. Am J Tranplant doi:10.1111/ajt.12029, 2012.
  • Troxell ML, Griffiths R, Schnadg I and Houghton DC. Light chain renal amyloidosis with prominent giant cells. Am J Kid Dis. 62:1193-7, 2013

Last Updated: 08/09/2010