Laura Kozell

Previous Positions

Postdoctoral fellow, Department of Behavioral Neuroscience, Oregon Health & Science University

National Alliance for Research on Schizophrenia And Depression (NARSAD) Young Investigator, Portland VA Medical Center (VAMC), Portland, OR.

Research Associate, Deptartments of Behavioral Neuroscience and Neurology, Oregon Health & Science University.

Education

B.S. (1987) Rutgers University, Cook College, New Brunswick, NJ
Ph.D. (1997) Dept. of Physiology & Pharmacology and the Neuroscience graduate program, Oregon Health & Science University

Research Interests

I am interested in pharmacological changes in brain neurotransmission systems following administration of alcohol or other drugs of abuse, such as methamphetamine and cocaine. I am also part of an effort to identify genes that are involved in alcohol withdrawal seizure susceptibility and to understand the functional relationship of these gene products in mouse strains that differ in susceptibility to drug withdrawal symptoms. I am also interested differences between patterns of drug-mediated brain activation in mouse strains that differ in susceptibility to drug withdrawal symptoms.

Selected Recent Publications

• Rubinstein M, Cepeda C, Hurst RS, Flores-Hernandez J, Ariano MA, Falzone TL, Kozell LB, Meshul CK, Bunzow JR, Low MJ, Levine MS, and Grandy DK. (2001). Dopamine D4 receptor-deficient mice display cortical hyperexcitability, J. Neurosci. 21:3756-3763.


• Kozell LB, and Meshul CK, (2001). The effects of acute or repeated cocaine administration on nerve terminal glutamate within the rat mesolimbic system, Neuroscience 106:115-125.


• Mason JN, Kozell LB, and Neve KA, (2002). Regulation of Dopamine D1 Receptor Trafficking by Protein Kinase A-Dependent Phosphorylation, Mol Pharmacol. 61:806-16.


• Kozell LB, and Meshul, CK, (2003). Alterations in nerve terminal glutamate immunoreactivity in the nucleus accumbens and ventral tegmental area following single and repeated doses of cocaine, Psychopharmacology 165:337-345.


• Kozell LB, and Meshul, CK, (2004). Nerve terminal glutamate immunoreactivity in the rat nucleus accumbens and ventral tegmental area after a short withdrawal from cocaine, Synapse 51:224-32.


• Torvinen M, Kozell LB, Neve KA, Agnati LF, Ibáñez CF, and Fuxe K, (2004). Biochemical identification of the dopamine D2 receptor domains interacting with the adenosine A2A receptor. Journal of Molecular Neuroscience 24:173-80.