QTL CodeEthypprov1 PARC Alias Ethyp2 MGI Alias
Drug Alcohol Phenotype Hypothermic Sensitivity
Assay Average difference from baseline of rectal body temperature measured at 30 and 60 minutes after 3 g/kg ethanol on day 1 of testing
Chromosome5Peak 59 Range
Max Range (Mb) Min Range (Mb) StatusSuggestive
LOD score2.1 p value0.002 Sex Specific
Strains Tested BXD RI, B6D2 F2 Increaser Allele Dominance
Contact Person J Crabbe Last Updated 2007-04-10 13:10:23


Crabbe JC, Phillips TJ, Gallaher EJ, Crawshaw LI, Mitchell SR. Common genetic determinants of the ataxic and hypothermic effects of ethanol in BXD/Ty recombinant inbred mice: genetic correlations and quantitative trait loci. J Pharmacol Exp Ther. 1996 M
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Crabbe JC, Belknap JK, Mitchell SR, Crawshaw LI. Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice. J Pharmacol Exp Ther. 1994 Apr;269(1):184-92.
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