Calw2/Alcdp2

QTL Code	Calw2/Alcdp2	PARC Alias	Calw2	MGI Alias	Alcdp2
Drug	Alcohol	Phenotype	Chronic Alcohol Withdrawal
Assay	Area under the curve for handling-induced convulsions over 25 hr period following 72 hr exposure to ethanol vapor
Chromosome	19	Peak	47	Range	36.5-ter
Max Range (Mb)	10.4 - 55.2	Min Range (Mb)	12.3 - 54.8	Status	Significant
LOD score	5.3	p value	6e-07	Sex Specific
Strains Tested	BXD RI, B6D2 F2	Increaser Allele	D2	Dominance
Comments	Mb intervals based on congenics studies
Contact Person	K. Buck	Last Updated	2007-04-05 11:06:28

References

Buck KJ, Rademacher BS, Metten P, Crabbe JC. Mapping murine loci for physical dependence on ethanol. Psychopharmacology (Berl). 2002 Apr;160(4):398-407. Epub 2002 Feb 15
Medline Link

Buck KJ, Finn DA. Genetic factors in addiction: QTL mapping and candidate gene studies implicate GABAergic genes in alcohol and barbiturate withdrawal in mice. Addiction. 2001 Jan;96(1):139-49.
Medline Link

Crabbe JC. Provisional mapping of quantitative trait loci for chronic ethanol withdrawal severity in BXD recombinant inbred mice. J Pharmacol Exp Ther. 1998 Jul;286(1):263-71.
Medline Link

Shirley RL, Buck KJ; unpublished data