QTL CodeCalw2/Alcdp2 PARC Alias Calw2 MGI AliasAlcdp2
Drug Alcohol Phenotype Chronic Alcohol Withdrawal
Assay Area under the curve for handling-induced convulsions over 25 hr period following 72 hr exposure to ethanol vapor
Chromosome19Peak 47 Range36.5-ter
Max Range (Mb)10.4 - 55.2 Min Range (Mb)12.3 - 54.8 StatusSignificant
LOD score5.3 p value6e-07 Sex Specific
Strains Tested BXD RI, B6D2 F2 Increaser AlleleD2 Dominance
Comments Mb intervals based on congenics studies
Contact Person K. Buck Last Updated 2007-04-05 11:06:28


Buck KJ, Rademacher BS, Metten P, Crabbe JC. Mapping murine loci for physical dependence on ethanol. Psychopharmacology (Berl). 2002 Apr;160(4):398-407. Epub 2002 Feb 15
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Buck KJ, Finn DA. Genetic factors in addiction: QTL mapping and candidate gene studies implicate GABAergic genes in alcohol and barbiturate withdrawal in mice. Addiction. 2001 Jan;96(1):139-49.
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Crabbe JC. Provisional mapping of quantitative trait loci for chronic ethanol withdrawal severity in BXD recombinant inbred mice. J Pharmacol Exp Ther. 1998 Jul;286(1):263-71.
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Shirley RL, Buck KJ; unpublished data