QTL CodeCalw1/Alcdp1 PARC Alias Calw1 MGI AliasAlcdp1
Drug Alcohol Phenotype Chronic Alcohol Withdrawal
Assay Area under the curve for handling-induced convulsions over 25 hr period following 72 hr exposure to ethanol vapor
Chromosome1Peak 96 Range89-106.3
Max Range (Mb)172.3 - 191.3 Min Range (Mb)172.9 - 186.9 StatusSignificant
LOD score7.6 p value2e-09 Sex Specific
Strains Tested BXD RI, B6D2F2, congenics Increaser AlleleD2 Dominance
Comments Mb intervals based on congenics studies
Contact Person K. Buck Last Updated 2007-04-04 13:20:40


Buck KJ, Rademacher BS, Metten P, Crabbe JC. Mapping murine loci for physical dependence on ethanol. Psychopharmacology (Berl). 2002 Apr;160(4):398-407. Epub 2002 Feb 15
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Buck KJ, Finn DA. Genetic factors in addiction: QTL mapping and candidate gene studies implicate GABAergic genes in alcohol and barbiturate withdrawal in mice. Addiction. 2001 Jan;96(1):139-49.
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Crabbe JC. Provisional mapping of quantitative trait loci for chronic ethanol withdrawal severity in BXD recombinant inbred mice. J Pharmacol Exp Ther. 1998 Jul;286(1):263-71.
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Kozell LM, Buck KJ; unpublished results