Calw1

QTL Code Calw1
Chromosome 1 ClassAlcohol
Peak 96 cMPhenotypeChronic Alcohol Withdrawal
Range 89-106.3 cM AssayArea under the curve for handling-induced convulsions over 25 hr period following 72 hr exposure to ethanol vapor
p Value 2e-09 Strains TestedBXD RI, B6D2F2, congenics
LOD Score 7.6StatusSignificant

References


Buck KJ, Rademacher BS, Metten P, Crabbe JC. Mapping murine loci for physical dependence on ethanol. Psychopharmacology (Berl). 2002 Apr;160(4):398-407. Epub 2002 Feb 15
Medline Link

Buck KJ, Finn DA. Genetic factors in addiction: QTL mapping and candidate gene studies implicate GABAergic genes in alcohol and barbiturate withdrawal in mice. Addiction. 2001 Jan;96(1):139-49.
Medline Link

Crabbe JC. Provisional mapping of quantitative trait loci for chronic ethanol withdrawal severity in BXD recombinant inbred mice. J Pharmacol Exp Ther. 1998 Jul;286(1):263-71.
Medline Link