Alcwprov1

QTL CodeAlcwprov1 PARC Alias Alcw5 MGI Alias
Drug Alcohol Phenotype Acute Alcohol Withdrawal
Assay Area under the curve for handling-induced convulsions 2-12h after 4 g/kg ethanol injection
Chromosome2Peak 60 RangeND
Max Range (Mb) Min Range (Mb) StatusSuggestive
LOD score2.1 p value0.002 Sex Specific
Strains Tested BXD RI, B6D2 F2, HAW/LAW Increaser AlleleB6 Dominance
Comments
Contact Person K. Buck Last Updated 2007-04-04 13:10:20

References


Buck KJ, Finn DA. Genetic factors in addiction: QTL mapping and candidate gene studies implicate GABAergic genes in alcohol and barbiturate withdrawal in mice. Addiction. 2001 Jan;96(1):139-49.
Medline Link

Buck KJ, Metten P, Belknap JK, Crabbe JC. Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice. J Neurosci. 1997 May 15;17(10):3946-55.
Medline Link