Alcw3

QTL Code	Alcw3	PARC Alias	Alcw3	MGI Alias	Alcw3
Drug	Alcohol	Phenotype	Acute Alcohol Withdrawal
Assay	Area under the curve for handling-induced convulsions 2-12h after 4 g/kg ethanol injection
Chromosome	11	Peak	20	Range	16-28
Max Range (Mb)	34.7 - 55.9	Min Range (Mb)	34.9 - 55.6	Status	Significant
LOD score	4.1	p value	1e-05	Sex Specific
Strains Tested	BXD RI, B6D2 F2, HAW/LAW	Increaser Allele	D2	Dominance
Comments	Mb intervals based on D1D2 SNP mapping
Contact Person	K. Buck	Last Updated	2007-04-04 13:11:51

References

Hood HM, Metten P, Crabbe JC, Buck KJ. Find mapping of a sedative-hypnotic drug withdrawal locus on mouse chromosome 11. Genes Brain Behav. 2006 Feb; 5(1):1-10.
Medline Link

Pletcher MT, McClurg P, Batalov S, Su AI, Barnes SW, Lagler E, Korstanje R, Wang X, Nusskern D, Bogue MA, Mural RJ, Paigen B, Wiltshire T. Use of a Dense Single Nucleotide Polymorphism Map for In Silico Mapping in the Mouse. PLoS Bio. 2004 Dec; 2(12):e393
Medline Link

Buck KJ, Finn DA. Genetic factors in addiction: QTL mapping and candidate gene studies implicate GABAergic genes in alcohol and barbiturate withdrawal in mice. Addiction. 2001 Jan;96(1):139-49.
Medline Link

Buck KJ, Metten P, Belknap JK, Crabbe JC. Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice. J Neurosci. 1997 May 15;17(10):3946-55.
Medline Link