Alcw3

QTL CodeAlcw3 PARC Alias Alcw3 MGI AliasAlcw3
Drug Alcohol Phenotype Acute Alcohol Withdrawal
Assay Area under the curve for handling-induced convulsions 2-12h after 4 g/kg ethanol injection
Chromosome11Peak 20 Range16-28
Max Range (Mb)34.7 - 55.9 Min Range (Mb)34.9 - 55.6 StatusSignificant
LOD score4.1 p value1e-05 Sex Specific
Strains Tested BXD RI, B6D2 F2, HAW/LAW Increaser AlleleD2 Dominance
Comments Mb intervals based on D1D2 SNP mapping
Contact Person K. Buck Last Updated 2007-04-04 13:11:51

References


Hood HM, Metten P, Crabbe JC, Buck KJ. Find mapping of a sedative-hypnotic drug withdrawal locus on mouse chromosome 11. Genes Brain Behav. 2006 Feb; 5(1):1-10.
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Pletcher MT, McClurg P, Batalov S, Su AI, Barnes SW, Lagler E, Korstanje R, Wang X, Nusskern D, Bogue MA, Mural RJ, Paigen B, Wiltshire T. Use of a Dense Single Nucleotide Polymorphism Map for In Silico Mapping in the Mouse. PLoS Bio. 2004 Dec; 2(12):e393
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Buck KJ, Finn DA. Genetic factors in addiction: QTL mapping and candidate gene studies implicate GABAergic genes in alcohol and barbiturate withdrawal in mice. Addiction. 2001 Jan;96(1):139-49.
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Buck KJ, Metten P, Belknap JK, Crabbe JC. Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice. J Neurosci. 1997 May 15;17(10):3946-55.
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