Alcw1

QTL CodeAlcw1 PARC Alias Alcw1 MGI AliasAlcw1
Drug Alcohol Phenotype Acute Alcohol Withdrawal
Assay Area under the curve for handling-induced convulsions 2-12h after 4 g/kg ethanol injection
Chromosome1Peak 96 Range66-ter
Max Range (Mb)172.3 - 174.0, 174.0 - 176.5 Min Range (Mb)172.9 - 174.0, 174.0 - 176.3 StatusSignificant
LOD score5.6 p value3e-07 Sex Specific
Strains Tested BXD RI, B6D2 F2, HAW/LAW Increaser AlleleD2 Dominance
Comments Two qtls in this interval. Mb intervals based on congenics studies
Contact Person K. Buck Last Updated 2007-04-04 13:08:20

References


Kozell LM, Walter NAR, Hofstetter J, Belknap JK, Buck KJ. Fine mapping of sedative-hypnotic withdrawal loci on mouse chromosome 1. J Neurosci. Submitted.

Buck KJ, Finn DA. Genetic factors in addiction: QTL mapping and candidate gene studies implicate GABAergic genes in alcohol and barbiturate withdrawal in mice. Addiction. 2001 Jan;96(1):139-49.
Medline Link

Buck KJ, Metten P, Belknap JK, Crabbe JC. Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice. J Neurosci. 1997 May 15;17(10):3946-55.
Medline Link

Kozell LM, Buck KJ; unpublished results