Alcw2

QTL Code	Alcw2	PARC Alias	Alcw2	MGI Alias	Alcw2
Drug	Alcohol	Phenotype	Acute Alcohol Withdrawal
Assay	Area under the curve for handling-induced convulsions 2-12h after 4 g/kg ethanol injection
Chromosome	4	Peak	38	Range	38-38.7
Max Range (Mb)	80.3 - 82.1	Min Range (Mb)	80.5 - 82.0	Status	Significant
LOD score	8.8	p value	2e-10	Sex Specific
Strains Tested	BXD RI, B6D2 F2, HAW/LAW	Increaser Allele	D2	Dominance
Comments	Mb intervals based on congenics studies
Contact Person	K. Buck	Last Updated	2007-04-04 13:11:36

References

Shirley RL, Walter NAR, Reilly MT, Fehr C, Buck, KJ. Mpdz is a quantitative trait gene for drug withdrawal seizures. Nat Neurosci. 2004 July; 7(7):699-700.
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Fehr C, Shirley RL, Belknap JK, Crabbe JC, Buck KJ. Congenic mapping of alcohol and pentobarbital withdrawal liability loci to a <1 centimorgan interval of murine chromosome 4: identification of Mpdz as a candidate gene. J Neurosci. 2002 May 1;22(9):3730
Medline Link

Buck KJ, Finn DA. Genetic factors in addiction: QTL mapping and candidate gene studies implicate GABAergic genes in alcohol and barbiturate withdrawal in mice. Addiction. 2001 Jan;96(1):139-49.
Medline Link

Buck KJ, Metten P, Belknap JK, Crabbe JC. Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice. J Neurosci. 1997 May 15;17(10):3946-55.
Medline Link