Research Component 2:
Animal and Dependence Core
Director: Tamara Phillips
Co-Director: Pamela Metten
The Animal and Dependence Core (Component 2) will provide services to all Components and Pilot Projects that require the use of mice. The objective of this Component is to streamline animal production, distribution and testing of key phenotypes for PARC-related, and when possible, other projects.
The Animal and Dependence Core will purchase mice for use in experiments or as breeders, will test mice for ethanol consumption, acute ethanol withdrawal and chronic ethanol withdrawal, and will perform blood and brain ethanol concentration analyses.
In collaboration with Research Components 5 and 7, the Core will oversee the selective breeding of mouse lines for high and low ethanol consumption, high and low acute ethanol withdrawal, and a composite phenotype of both consumption and withdrawal.
The Animal Core will also maintain mice for an embryonic gene expression analysis to be performed by the Molecular Genetics Support Core (Component 3) and will assist in the development of a BAC transgenic if needed for pursuit a candidate gene hypothesis.
The Dependence Division of the Core will continue to optimize procedures both dependence induction and ethanol concentration analysis. The Animal and Dependence Core will determine animal distribution and phenotyping priorities, and will maintain a data spreadsheet with individual animal information that can be communicated to investigators and to the Microarray, Bioinformatics and Biostatistics Core (Component 4).
Finally, the Core will maintain previously created and new genetic animal models that exist nowhere else and will make them available to investigators as requested.
As has been case for the past and current years of the PARC, the breeding, production, procurement and supply of the genetic animal models to be employed will remain under the direction of Dr. Tamara Phillips. Dr. Phillips also has responsibility for oversight of the ethanol consumption data collection.
As has been the case for the current 5-year funding period, Dr. Pamela Metten will take responsibility for oversight of the Dependence Division of the Core, which will include optimization of measurements, scheduling of experiments, data collection, organization and summarization.
by Mark Rutledge-Gorman
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