Mouse
Mouse Genetic Models

Researchers of the PARC utilize many genetic animal models in their work. The following mouse genetic models were developed locally and are now available to the research community.

If you are interested in obtaining one of our currently available mouse models, please click the appropriate contact link to email that person directly.

Selectively Bred Lines


Line DesignationDescriptionContact
FAST-1, FAST-2, SLOW-1, SLOW-2


Phillips et al., 1991 		FAST replicate 1&2 and SLOW replicate 1&2.
Lines were bred to display heightened (FAST) or reduced (SLOW) sensitivity to the locomotor activating effects of a single 2.0 g/kg IP injection of ethanol, compared to response after saline injection. 		Tamara Phillips
WSP-1, WSP-2,
WSR-1, WSR-2


Crabbe et al., 1985 		Withdrawal Seizure-Prone replicate 1&2 and Withdrawal Seizure-Resistant replicate 1&2.
Lines were bred to display severe (WSP) or mild (WSR) handling-induced convulsions after withdrawal from chronic ethanol vapor inhalation. 		John Crabbe
WSC-1, WSC-2 Withdrawal Seizure Control replicate 1&2.
Randomly bred controls bred in parallel with WSP and WSR selected lines. 		John Crabbe
IWSP-1, IWSP-2, IWSR-1, IWSR-2 Inbred strains derived from WSP & WSR selectively bred lines, beginning with generation S26G33-52. Fully inbred. Live mice are available from IWSP-2 and IWSR-1, for the other two strains sperm are cryopreserved. John Crabbe
HOT-1, HOT-2, COLD-1, COLD-2


Crabbe et al., 1987 		HOT & COLD mouse lines were selectively bred for extreme (COLD) or mild (HOT) hypothermia 30-60 minutes after 3 g/kg ethanol, and are all currently embryo cryopreserved. John Crabbe


All selectively bred lines were bred bi-directionally (high vs low) over 26 or more generations for the trait indicated from founder populations of the HS/Ibg 8-way inbred strain cross (available from the Institute of Behavior Genetics, Boulder, CO). Independently-derived replicated lines were developed for all three selections (FAST/SLOW, WSP/WSR, HOT/COLD).

Short Term Selectively Bred (STSB) lines are periodically developed by PARC Researchers for use in gene mapping and microarray studies for various behavioral traits. Contact Michelle Bobo for information regarding availability of data or animals.

Congenic Strains
Purple: B6.D2 strains
Green: D2.B6 strains

Chr. 1

Strain Name Chr: cM Mb
B6.D2-D1MIT200,150 1:73-102 152.0 - 176.4
D2.B6-D1MIT200,150 1:73-102 152.0 - 176.4
B6.D2 Chr 1 MtvTy/7a (D1MIT113,291) 1:93.3 - 101 172.9 - 188.0
B6.D2 R4 1* 172.9 - 177.9
B6.D2 R7 1* 183.4 - 188.0
B6.D2 ISCS6 1* 172.9 - 176.3
B6.D2 ISCS8 1* 172.9 - 174.0
B6.D2 ISCS9 1* 174.4 - 176.3

Chr 2

B6.D2-D2MIT80,285 control 2:10-86 20.9 - 1152.5
B6.D2-D2MIT80,285 congenic 2:10-86 20.9 - 152.5
D2.B6-D2MIT91,164 control 2:37-71 66.5 - 123.1
D2.B6-D2MIT91,164 congenic 2:37-71 66.5 - 123.1

Chr 4

D2.B6-Tyrp1(D4MIT192,327) 4:6-42 31.3 - 85.9

Chr 9

B6.D2-D9MIT90,182 9:9-58 32.6 - 101.4
D2.B6-D9MIT90,18 9:9-71 32.6 - 120.1
B6.D2-D9MIT90,18 9:9-71 32.6 - 120.1
B6.D2-D9MIT90,206 9:9-20 32.6 - 40.7
B6.D2-D9MIT90,4 9:9-29 32.6 - 52.5
B6.D2-D9MIT325,71 9:14-29 34.3 - 50.3
B6.D2-D9MIT93,4 9:27-29 46.5 - 52.5
B6.D2-D9MIT129,50 9:26-49 43.9 - 94.3
B6.D2-D9MIT96,115 9:29-56 50.8 - 102.3
B6.D2-D9MIT142,115 9:31-56 56.8 - 102.3
B6.D2-D9MIT325,206 9:14-20 34.3 - 40.7
B6.D2-D9MIT31,271 9:35-43 63.9 - 87.5

Chr 11

D2.B6-D11MIT82,258 11:14-65 25.9 - 107.5

Chr 19

D2.B6-D19MIT68,126 19:3-8 3.5 - 10.4
D2.B6-D19MIT13,137 19:33-55.7 32.3 - 59.0
D2.B6-D19MIT109,61 19:4-9 6.1 - 15.2
D2.B6-D19MIT109,63 19:4-24 6.1 - 37.5
D2.B6-D19MIT79,13 19:6-33 12.3 - 32.3
D2.B6-D19MIT80,63 19:22-24 23.0 - 37.5
D2.B6-D19MIT79,95 19:6-10 12.3 - 14.4
D2.B6-D19MIT79,41 19:6-16 12.3 - 16.4
D2.B6-D19MIT109,95 19:4-10 6.1 - 14.4
D2.B6-D19MIT109,137 19:4-55.7 6.1 - 59.0
D2.B6-D19MIT70,55 19:51-53 50.6 - 55.2
D2.B6-D19MIT103,137 19:52-55.7 55.2 - 59
D2.B6-D19MIT79,1 19:6-52 12.3 - 54.8
D2.B6-D19MIT13,91 19:33-47 32.3 - 47.0
D2.B6-D19MIT19,91 19:26-47 39.3 - 47.0
D2.B6-D19MIT13,100 19:27-33 32.2 - 42.3

List of Congenic Strains that the PARC Currently has Cryopreserved

Strain Name Chr: cM Mb
D2.B6-Chr4 ISCS2 4:21.9-38.6 33.6 – 80.7

D2.B6-Mpdz        

4:37.7-38.6 79.0 – 80.7
D2.B6-Chr4 ISCS4 4:6.3-37.6 31.3 – 73.9

by Mark Rutledge-Gorman
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