Mouse Genetic Models Mouse

Researchers of the PARC utilize many genetic animal models in their work. The following mouse genetic models were developed locally and are now available to the research community.

If you are interested in obtaining one of our currently available mouse models, or a cryopreserved model, please contact Dr. Tamara Phillips, PARC Animal and Phenotyping Core Director.

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Selectively Bred Lines
Congenic Strains (live)
Congenic Strains (cryopreserved)

Selectively Bred Lines

Line Designation Description Developing PI
FAST-1, FAST-2, SLOW-1, SLOW-2
FAST replicate 1&2 and SLOW replicate 1&2.
Lines were bred to display heightened (FAST) or reduced (SLOW) sensitivity to the locomotor activating effects of a single 2.0 g/kg IP injection of ethanol, compared to response after saline injection; all are embryo cryopreserved and available from the MMRRC.

Tamara Phillips

Phillips et al., 1991

WSP-1, WSP-2,
WSR-1, WSR-2

Withdrawal Seizure-Prone replicate 1&2 and Withdrawal Seizure-Resistant replicate 1&2.
Lines were bred to display severe (WSP) or mild (WSR) handling-induced convulsions after withdrawal from chronic ethanol vapor inhalation. Live mice are available.

John Crabbe

Crabbe et al., 1985

WSC-1, WSC-2 Withdrawal Seizure Control replicate 1&2.
Randomly bred controls bred in parallel with WSP and WSR selected lines. Live mice are available.
John Crabbe
IWSP-1, IWSP-2, IWSR-1, IWSR-2 Inbred strains derived from WSP & WSR selectively bred lines, beginning with generation S26G33-52. Fully inbred. Live mice are available from IWSP-2 and IWSR-1; for the other two strains, sperm are cryopreserved. John Crabbe

HOT-1, HOT-2, COLD-1, COLD-2
HOT & COLD mouse lines were selectively bred for extreme (COLD) or mild (HOT) hypothermia 30-60 minutes after 3 g/kg ethanol. Embryos are cryopreserved.

John Crabbe

Crabbe et al., 1987


HDID-1, HDID-2

The HDID replicate mouse lines are being actively selectively bred for high blood ethanol concentrations after consumption of ethanol (20%) in a limited access period of 4 hours called, "Drinking in the Dark (DID)."

John Crabbe

Crabbe et al., 2009

HAFT-1, LAFT-1
The High Acute Functional Tolerance (HAFT) and Low Acute Functional Tolerance (LAFT) replicate 1 mouse lines were selectively bred by Drs. Erwin & Deitrich (UCHSC, Denver, CO) to display high (HAFT) or low (LAFT) acute functional tolerance to ethanol, calculated as the difference in blood ethanol concentrations at the time of regaining the ability to stay for 1 minute on a stationary dowel (12.7mm) after two consecutive injections of ethanol (1.75 g/kg followed by 2.0 g/kg, IP). Embryos are cryopreserved and available from the MMRRC.

John Crabbe

Erwin and Deitrich 1996



FAST/SLOW, WSP/WSR, HOT/COLD, and HAFT/LAFT selections were bred bi-directionally (high vs low) over 15 or more generations for the trait indicated from the founder populations of the HS/Ibg 8-way inbred strain cross (formerly available from the Institute of Behavior Genetics, Boulder, CO). Independently-derived replicated lines were developed for all four selections. The HAFT/LAFT selection was created by Dr. V. G. Erwin (UCHSC, Denver, CO) and breeding stock of the first replicate were provided to Dr. Crabbe in 2006.

HDID selections are being bred uni-directionally (high lines only) for the trait indicated from founder populations of the HS/Npt 8-way inbred strain cross (available from Dr. R. Hitzemann, OHSU, Portland, OR). These replicated lines are at 22 and 15 generations, respectively (November, 2011).

Short Term Selectively Bred (STSB) lines are periodically developed for various behavioral traits by PARC Researchers for use in gene mapping and microarray studies.

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Congenic Strains

PURPLE: B6.D2 strains
AQUA: D2.B6 strains
BLACK: IWSP.IWSR strains
ORANGE: D1.D2 strains

Contact: Dr. Tamara Phillips

Strain Name Developing PI Chr: cM Mb Status
Chr. 1
D2.B6-Chr 1-ISCS2 Buck 1:87-100 169.2-176.4 Full congenic
D2.B6-Chr 1-ISCS3 Buck 1:87-94 169.2-173.3 Full congenic
B6.D2-Chr 1-ISCS6 Buck 1:92-100 172.9-176.3 Full congenic
B6.D2-Chr 1-ISCS8 Buck 1:92-94 172.9-174.0 Full congenic
B6.D2-Chr 1-ISCS9 Buck 1:94-100 174.4-176.3 Full congenic
B6.D2-Chr 1-ISCS12 Buck 1:92-96 172.8-174.4 Full congenic
IWSP.IWSR-D1MIT7,30 Belknap 1:38-58 75-135 Full congenic
Chr 2
D2.B6-D2MIT91,164 control Phillips 2:10-86 66.5-123.1 Full congenic
D2.B6-D2MIT91,164 congenic Phillips 2:10-86 66.5-123.1 Full congenic
D2.B6-Chr 2-ISCS1 Phillips 2:37-49.6 66.5-85.7 Full congenic
D2.B6-Chr 2-ISCS2a Phillips 2:49.6-50.3 85.7-99.2 Full congenic
D2.B6-Chr 2-ISCS2b Phillips 2:37-50.3 66.5-99.2 Full congenic
D2.B6-Chr 2-ISCS2c Phillips 2:47.9-50.3 79.9-99.2 Full congenic
D2.B6-Chr 2-ISCS3 Phillips 2:47.5-71 101.7-123.2 Full congenic
D2.B6-Chr 2-ISCS4 Phillips 2:51.4-71 108-123.2 Full congenic
D2.B6-Chr 2-ISCS5 Phillips 2:52.5-71 113.2-123.2 Full congenic
Chr 8
IWSP.IWSR-D8Mit94,312 Belknap 8:18-48 32.4-98 Full congenic
Chr 9
D2.B6-D9Mit90,18 Phillips 9:9-71 32.6 - 120.1 Full congenic
Chr 11
D2.B6-D11Mit82-258 Buck 11:2-65   Full congenic
D1.D2-D11Mit217-140 Buck 11:19-28 37.4-54 Full congenic
IWSP.IWSR-D11Mit340,160 Belknap 11:14-60 23.1-96.7 Full congenic
Chr 14
IWSP.IWSR-D14Mit54,265 Belknap 14:20-51 36.1-101.7 Full congenic
Chr 19
D2.B6 D19Mit19,91 Buck 19:26-47 39.3 - 47.8 Full congenic

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Congenic Strain That Have Been Cryopreserved


Strain Name

Developing
PI

Chr: cM Mb Cryo
Llocation
Cryo
PI
Tissue
Chr 1
B6.D2-D1MIT200,150 Buck 1:73-102 152.0-176.4 OHSU Phillips sperm
D2.B6-D1MIT200,150 Buck 1:73-102 152.0-176.4 OHSU Phillips sperm
B6.D2-Chr 1-R4 Buck 1:78-82 172.9-177.9 OHSU Buck embryo
B6.D2-Chr 1-R8 Buck 1:78-79.5 172.9-174 OHSU Buck embryo
B6.D2-Chr 1-MtvTy/7a (D1MIT113,291) Buck 1:93.3-101 173.6-186.4 JAX Phillips sperm
Chr 2
B6.D2-D1MIT80,285 control Klein 2:10-86 20.9-152.5 JAX Phillips sperm
B6.D2-D1MIT80,285 congenic Klein 2:10-86 20.9-152.5 JAX Phillips sperm
D2.B6-D2MIT91,164 control Klein 2:37-71 66.5-123.1 JAX Phillips sperm
D2.B6-D2MIT91,164 congenic Klein 2:37-71 66.5-123.1 JAX Phillips sperm
Chr 4
D2.B6-Tyrp1 (D4MIT192,327) Buck 4:6-42 31.1-86.1 OHSU   sperm
D2.B6-Chr4 ISCS2 Buck 4:21.9-38.6 53.6-81 OHSU Phillips sperm
D2.B6-mpdz Buck 4:37.7-38.6 75.1-76.5 OHSU Phillips sperm
D2.B6-Chr4 ISCS 4 Buck 4:6.3-37.6 31.3-75.1 OHSU Phillips sperm
Chr 9
B6.D2-D9MIT90,182 Phillips 9:9-58 32.6-101.4 OHSU sperm
D2.B6-D9MIT90,18 Phillips 9:9-71 32.6-120.1 OHSU sperm
B6.D2-D9MIT90,18 Phillips 9:9-71 32.6-120.1 JAX sperm
B6.D2-D9MIT31,144 Phillips 9:35 63.6-63.8 JAX sperm
D2.B6-D9MIT129,71 congenic Phillips 9:26-29 43.6-50 JAX sperm
D2.B6-D9MIT129,71 control Phillips 9:26-29 43.6-50 JAX sperm
Chr 11
D2.B6-D11MIT78,179 Buck 11:2-52 17.8-89.6 OHSU Buck sperm
D2.B6-D11MIT82,258 Buck 11:14-65 25.9-107.5 JAX Phillips sperm
Chr 19
D2.B6-D19MIT109,137 Buck 19:4-55.7 6.1-59 OHSU Buck sperm


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by Andy Jade Cameron

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