PORTLAND, Ore. – Gleevec, a pill developed in conjunction with the Oregon Health & Science University Cancer Institute is again showing excellent results in preventing a cancer recurrence.
In a major news release from the National Institutes of Health today it was stated that: preliminary results from a large, randomized, placebo-controlled clinical trial for patients with primary gastrointestinal stromal tumor (GIST) showed that patients who received imatinib mesylate (Gleevec) after complete removal of their tumor were significantly less likely to have a recurrence of their cancer compared to those who did not receive Gleevec.
The clinical trial was sponsored by the National Cancer Institute, part of the National Institutes of Health, and conducted by a network of researchers led by the American College of Surgeons Oncology Group.
"This is a major breakthrough that will change the way this type of cancer is treated," said Charles Blanke, M.D., F.A.C.P., leader of the Solid Tumors Program at the OHSU Cancer Institute and professor of medicine (hematology and medical oncology).
Researchers in the multi-site study found that approximately 97 percent of patients who received Gleevec one year after surgery were alive without a recurrence of their cancer, compared to 83 percent who received one year of a placebo. It was also found that Gleevec was well tolerated by most patients in the study. Mild side effects included nausea, diarrhea and swelling. More than 700 patients were enrolled in the study. Patients on placebo who had a recurrence of their cancer were given Gleevec.
The OHSU Cancer Institute, with Blanke as the principal investigator, was one of the largest study sites for this phase III double-blind trial with 28 GIST patients enrolled from January 2003 through February 2007. Gleevec works by blocking cellular communication to prevent tumor growth.
Gleevec was initially developed at the OHSU Cancer Institute by Brian Druker, M.D., in collaboration with scientists at Novartis, as a treatment for patients with chronic myelogenous leukemia. In addition to GIST, it is also being used as a potential therapy for certain types of blood and skin cancers.
GIST affects about 5,000 to 10,000 Americans a year, striking any of the organs in the entire length of the gastrointestinal tract or its lining. These tumors are prone to spread to other organs and, once spread, they often are unresponsive to chemotherapy or radiation, and invariably used to be fatal. Another study, led by OHSU investigators, showed Gleevec benefits 90 percent of GIST patients with metastatic disease.
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The OHSU Cancer Institute is the only cancer center designated by the National Cancer Institute between Sacramento and Seattle. It comprises some 120 clinical researchers, basic scientists and population scientists who work together to translate scientific discoveries into longer and better lives for Oregon's cancer patients. In the lab, basic scientists examine cancer cells and normal cells to uncover molecular abnormalities that cause the disease. This basic science informs more than 200 clinical trials conducted at the OHSU Cancer Institute.
