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OHSU Division of Hematology and Medical Oncology
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Dedicated to the study and treatment of cancer and disorders of the blood.

 
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Our Faculty

Charles D. Lopez, M.D., Ph.D.
Assistant Professor
Fellowship Program Director

Specialty: Tumor Biology and GI Medical Oncology

Clinic Phone: 503-494-6594
Lab Phone: 503-494-6525
E-mail: lopezc@ohsu.edu

 

My major research interest is the laboratory investigation into the basic cellular and molecular mechanisms underlying tumor formation and response to therapy. By studying these complex mechanisms, I ultimately hope to identify molecular targets for novel cancer therapies. My clinical focus is in the area of gastrointestinal oncology and I am actively involved in clinical trials for a variety of GI malignancies.

 
Appointments

  • Assistant Professor, Department of Medicine, Hematology/Oncology
  • Assistant Professor, Cell & Developmental Biology

 

Professional Education and Training

Education:
  • 1982 B.S., Microbiology, Stanford University.
  • 1990 Ph.D., Endocrinology/Cell Biology, University of California San Francisco.
  • 1991 M.D., University of California San Francisco.
Post-graduate training:
  • 1991-94 Medical Resident, University of California San Francisco Medical Center.
  • 1995-1998 Medical Oncology Fellow, Stanford University Medical Center.
  • 1998-2001 Postdoctoral Fellow, Medical Oncology, Stanford University.
Personal

 
Selected Publications

  • Chen D, Yu Z, Zhu Z, and Lopez CD. The p53 pathway promotes efficient mitochondrial DNA base excision repair in colorectal cancer cells. Cancer Research. 2006 Apr 1;66(7):3485-94.
  • Zhu Z, Ramos J, Kampa K, Adimoolam S, Sirisawad M, Yu Z, Chen D, Naumovski L, and Lopez CD."Control of ASPP2/(53BP2L) protein levels by proteasomal degradation modulates p53 apoptotic function." Journal of Biological Chemistry 280(41): 34473 (2005). Read More
  • D. Chen, E. Padiernos, F. Ding, I. Lossos, and C. D. Lopez. "Apoptosis Stimulating Protein of p53-2 (ASPP2/53BP2L) is an E2F Target Gene." Cell Death and Differentiation. epub ahead of print Dec 10 (2004). Read more
  • H. Qian, T. Wang, L. Naumovski, C. D. Lopez, and R. K. Brachmann. "Groups of p53 Target Genes Involved in Specific p53 Downstream Effects Cluster into Different Classes of DNA Binding Sites." Oncogene 21(51): 7901 (2002). Read more
  • I. Lossos, Y. Natkunam, R. Levy, and C. D. Lopez. "Apoptosis Stimulating Protein of p53 (ASPP2) Expression Differs Between Diffuse Large B-Cell and Follicular Center Lymphoma: Correlation With Clinical Outcome." Leukemia and Lymphoma 43(12): 2309 (2002). Read more
  • C. D. Lopez, G. Martinovsky, and L. Naumovski. "Inhibition of Cell Death by Ribosomal Protein L35a." Cancer Letters 180:195 (2002). Read more
  • C. D. Lopez, Y. Ao, L. H. Rohde, T. D. Perez, D. J. O'Connor, X. Lu, J. M. Ford, and L. Naumovski."Pro-Apoptotic p53-Binding Protein 53BP2 is Induced by UV-Irradiation but Suppressed by p53." Molecular and Cellular Biology 20(21): 8018 (2000).
  • C. S. Yost, C. D. Lopez, S. B. Prusiner, R. M. Myers, and V. R. Lingappa. "Non-hydrophobic Extracytoplasmic Determinant of Stop Transfer in the Prion Protein." Nature 343: 669-672 (1990). Read more
  • C. D. Lopez, C. S. Yost, S. B. Prusiner, R. M. Myers, and V. R. Lingappa. "Unusual Topogenic Sequence Directs Prion Protein Biogenesis." Science 248: 226-229 (1990). Read more

    Search PubMed for more publications.