| Meet the Staff
Michael Gough, PhD Title:
Clinical Research Assistant Professor
Publications:
1. (1999) 'Different approaches in the gene therapy of cancer [Review]'. Gough, MJ, Vile, RG. Trends in Exper Med. 9: 225-236.
2. (1999) 'Apoptosis or necrosis for tumour immunotherapy - what’s in a name? [Review]'. Melcher, A, Gough, MJ, Todryk, S, Vile, R. J Mole Med 77: 824-33.
3. (1999) 'The potential use of laser capture microdissection to selectively obtain distinct populations of cells for proteomic analysis - Preliminary findings'. Banks, RE, Dunn, MJ, Forbes, MA, Stanley, A, Pappin, D, Naven, T, Gough, MJ, Harnden, P, Selby, PJ. Electrophoresis 20: 689-700.
4. (2000) 'PKC-d is an apoptotic lamin kinase'. Cross T, Griffiths G, Deacon E, Sallis R, Gough MJ, Watters D & Lord JM. Oncogene 19: 2331-2337.
5. (2001) 'Macrophages orchestrate the immune response to tumor cell death'. Gough, MJ, Melcher, AA, Ahmed, A, Crittenden, MR, Riddle, DS, Linardakis, E, Ruchatz, AN, Emiliusen, LM, Vile, RG. Canc Res 61(19):7240-7.
6. (2001) 'Cell death associated with genetic prodrug activation therapy of colorectal cancer'. Todryk S, Melcher A, Bottley G, Gough MJ, Vile R. Cancer Letters 174(1): 25-33.
7. (2001) 'A transcriptional feedback loop for tissue specific expression of highly cytotoxic genes which incorporates an immunostimulatory component'. †Gough MJ, †Emiliusen L, Bateman A, Voellmy R, Chester J, Diaz RM & Vile R. Gene Therapy 8: 987-998.
8. (2001) 'Renal carcinoma cell lines inhibit natural killer activity via the CD94 receptor molecule'. †Gough MJ, †Stanley AJ, Banks RE, Selby P & Patel PM. Cancer Immunology & Immunotherapy. 50: 260-268.
9. (2002) 'Tumor antigen-specific induction of transcriptionally targeted retroviral vectors from chimeric immune receptor-modified T cells'. †Chester, J, †Ruchatz, A, Gough, MJ, Crittenden, M, Chong, H, Loic-Cosset, F, Diaz, RM, Harrington, K, Alvarez-Vallina, L, Vile, R. Nat Biotechnol 20:256-63.
10. (2002) 'Dendritic cells for the immunotherapy of cancer [Review]'. Melcher, A, Bateman, A, Harrington, K, Ahmed, A, Gough, MJ, Vile, R. Clin Oncol (R Coll Radiol). 14(3):185-92.
11. (2002) 'Cells as vehicles for cancer gene therapy: the missing link between targeted vectors and systemic delivery? [Review] Human Gene Therapy'. Harrington, K, Alvarez-Vallina, L, Crittenden, M, Gough, MJ, Chong, H, Diaz, RM, Vassaux, G, Lemoine, N, Vile, R. 13(11):1263-80.
12. (2002) 'Enhancing the efficacy of a weak allogeneic melanoma vaccine by viral fusogenic membrane glycoprotein-mediated tumor cell-tumor cell fusion'. Linardakis, E, Bateman, A, Phan, V, Ahmed, A, Gough, MJ, Olivier, K, Kennedy, R, Errington, F, Harrington, KJ, Melcher, A, Vile, R. Canc Res 62:5495-5504.
13. (2002) 'Viral fusogenic membrane glycoproteins kill solid tumor cells by non-apoptotic mechanisms which promote cross presentation of tumor antigens by dendritic cells'. Bateman, AR, Harrington, KJ, Kottke, T, Ahmed, A, Melcher, AA, Gough, MJ, Linardakis, E, Riddle, D, Dietz, A, Lohse, CM, Strome, S, Peterson, T, Simari, R, Vile, RG. Canc Res. 62(22):6566-78.
14. (2003) 'Intradermal injection, as opposed to subcutaneous injection, enhances immunogenicity and suppresses tumorigenicity of tumor cells'. Bonnotte B, Gough MJ, Phan V, Ahmed A, Chong H, Martin F, Vile RG. Canc Res. 63(9):2145-9.
15. (2003) 'A new genetic method to generate and isolate small, short-lived but highly potent dendritic cell-tumor cell hybrid vaccines'. Phan, V, Errington, F, Cheong, SC, Kottke, T, Gough, MJ, Altmann, S, Brandenburger, A, Emery, S, Strome, S, Bateman, A, Bonnotte, B, Melcher, A, Vile, R. Nat Med. 9(9):1215-9.
16. (2003) 'Facets of heat shock protein 70 show immunotherapeutic potential [Review] Immunol'. Todryk, SM, Gough, MJ, Pockley, AG. 110(1):1-9.
17. (2003) 'Pharmacologically regulated production of targeted retrovirus from T cells for systemic anti-tumor gene therapy'. †Gough, MJ, †Crittenden, MR, Chester, J, Kottke, T, Thompson, J, Ruchatz, A, Clackson, T, Luic Cosset, F, Chong, H, Diaz, R-M, Harrington, K, Alvarez Vallina, L, Vile, RG. Canc Res. 63:3173-8.
18. (2003) 'Expression of Inflammatory Chemokines Combined with Local Tumor Destruction Enhances Tumor Regression and Long-Term Immunity'. Crittenden, M, Gough, MJ, Harrington, K, Olivier, K, Thompson, J, Vile, RG. Canc Res. 63:5505-12.
19. (2004) 'Gene Therapy for Renal Cancer [Review] in Genetics of Renal Disease'. Gough, MJ, Vile, RG. Eds: Flinter, Maher and Saggar-Malik Oxford University Press, Oxford, UK. ISBN:0-19-263146-2.
20. (2004) 'A simple method to cure established tumors by inflammatory killing of normal cells'. Daniels, GA, Sanchez-Perez, L, Diaz, RM, Kottke, T, Thompson, J, Lai, M, Gough, MJ, Karim, M, Bushell, A, Chong, H, Melcher, A, Harrington, K, Vile, RG. Nat Biotech 22(9):1125-32.
21. (2004) 'Induction of cell stress through gene transfer of an engineered heat shock transcription factor enhances tumor immunogenicity'. Gough, MJ, Melcher, AA, Crittenden, MR, Sanchez, L, Voellmy, R, Vile, RG. Gene Therapy 11(13): 1099-104.
22. (2004) 'MIP-3? Transfection into a Rodent Tumor Cell Line Increases Intratumoral Dendritic Cell Infiltration but Enhances (Facilitates) Tumor Growth and Decreases Immunogenicity'. Bonnotte, B, Crittenden, M, Larmonier, N, Gough, MJ, Vile, RG. J Immunol 173:4929-4935.
23. (2005) 'Gene therapy to manipulate effector T cell trafficking to tumors for immunotherapy'. Gough, MJ, Crittenden, MR, Thanarajasingham, U, Sanchez-Perez, L, Thompson, J, Jevremovic, D, Vile, RG. J Immunol 174:5766-73.
24. (2005) 'Intratumoral Immunotherapy: strategies that use the tumor site to enhance anti-tumor immunity'[Review]. Crittenden, MR, Thanarajasingham U, Vile, RG, Gough, MJ. Immunol 114:11-22.
25. (2006) 'Fusogenic membrane glycoprotein-mediated tumour cell fusion activates human dendritic cells for enhanced IL-12 production and T-cell priming'. Errington F, Jones J, Merrick A, Bateman A, Harrington K, Gough M, O’Donnell D, Selby P, Vile R, Melcher A; Gene Therapy. 13(2): 138-49.
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