David Lewinsohn

Primary Affiliation

Program Affiliation

Lewinsohn Laboratory: CD8 T Cell Recognition of Intracellular Infection with Mtb

The Lewinsohn laboratory is focused on understanding the mechanisms by which human CD8+ T cells recognize cell infected with Mycobacterium tuberculosis (Mtb), the bacteria responsible for tuberculosis. Areas of interest within the laboratory include:

1) Defining the repertoire of immunodominant antigens in Mtb.  Here, we have focused on antigens that are presented by classical HLA molecules (HLA-A, B, and C) as well as those presented by non-classical molecules such has HLA-E.

2) Defining the mechanisms by which Mtb-antigens can enter the HLA-I antigen processing pathway.  Because Mtb is an organisms normally found within the phagosome (traditionally a HLA-II processing compartment). We are currently focused on the role of the phagosome as a HLA-I processing compartment.

3) Defining the mechanisms by which innate T cells can recognize those cells infected with Mtb.  Here, early recognition of these cells might directly limit intracellular replication of Mtb, or might promote the development of an effective adaptive immune response.

Preceptor Rotations

Dr. Lewinsohn has not indicated availability for preceptor rotations at this time.

Faculty Mentorship

Dr. Lewinsohn is available as a mentor for 2008-2009.