Summary of Current Research

A primary focus of my research is to explore neuronal development and migratory pathways. We have determined the time period when dopamine neurons, dopamine receptors and specific dopamine target neurons such as enkephalin, dynorphin and gamma aminobutryc acid (GABA) neurons first appear in fetal rhesus monkey brain. Currently, we are investigating the effects of cocaine on the development of this dopamine neurocircuitry that control behavior and motor functions. The dopamine neurons are a primary target for cocaine, and we have found that cocaine has significant actions on several components of the dopamine neurocircuitry already during the first trimester of gestation. We have cloned several rhesus monkey-specific cDNA fragments that are used in nuclease protection assay and in situ hybridization to study alterations in gene expression within the dopamine neurocircuitry in cocaine-exposed fetal monkeys. The long range goals are to determine long-term, perhaps permanent alterations that occur in the signaling properties of dopamine receptive neurons due to cocaine exposure during a critical period in development.

Research in my laboratory is also aimed at studying hypothalamic control of the female reproductive cycle. Specifically, we are investigating the actions of ovarian steroids (estrogen and progesterone) in the brain to induce prevolatory GnRH and LH surges. These studies include analysis at the cellular and molecular level of steroid modulation of excitatory and inhibitory input to hypothalamic neurons.

Education

• Ph.D., University of Texas Health Sciences Center, 1974

Preceptor Rotations

Dr. Ronnekleiv has not indicated availability for preceptor rotations at this time.

Faculty Mentorship

Dr. Ronnekleiv has not indicated availability as a mentor at this time.