Summary of Current Research

I am interested in how neurons communicate with each other. At the molecular level, these cells express an array of proteins that are organized into several complex signaling systems. The system that I have chosen to study is composed of a receptor protein that is coupled to an effector molecule via a GTP-binding protein. The G protein-coupled receptors constitute a large family of molecules that share several structural features yet are diverse with respect to the ligands that they bind and the second messenger systems that they modulate. Taking advantage of the sequence that is conserved between known G protein-coupled receptors, we have employed two strategies which led to the cloning of several dopamine receptors as well as a novel orphan receptor that is homologous to the opioid receptors. We recently discovered the endogenous peptide ligand for this orphan receptor and have demonstrated that one function of orphanin FQ-nociceptin (OFQ-N) is to functionally antagonize the actions of morphine. We are currently using a combination of molecular, cellular, and behavioral approaches to explore the involvement of the dopamine and OFQ-N receptors in the development of opiate tolerance and drug dependence.

Education

Ph.D. 1985, Michigan State University

Preceptor Rotations

Dr. Grandy has not indicated availability for preceptor rotations at this time.

Faculty Mentorship

Dr. Grandy might be available as a mentor for 2008-2009.