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Oregon Health & Science Univ
Molecular & Medical Genetics
Mail Code: L103
3181 SW Sam Jackson
Park Road
Portland, OR 97239
503-494-7703
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H. Scott Stadler, Ph.D. - Associate Professor
Oregon Health & Science University
3181 SW Sam Jackson Park Road
Mail Code SHC-RES
Portland, OR 97239
Office: 503-221-3447
Fax: 503-221-3451
E-Mail: hss@shcc.org
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 Nearly 60% of all human congenital defects manifest as malformations in the limb, genitourinary, or craniofacial regions. Recognizing the prevalence of birth defects in these regions, the goal of my research group is to identify and to functionally characterize genes that play a major role in the development of these structures. In particular, our group is analyzing how Hox genes mediate the patterning of specific tissues and structures in these affected regions. Using gene targeting in mice, mutations in developmental genes are produced and characterized to discern the mechanism(s) of gene function required for normal growth and development. Recently, we have been able to tag these mutations with a green fluorescent protein reporter, GFP. Our use of GFP in association with gene targeting has greatly enhanced our ability to view malformations as they occur in the living embryo. In addition, the GFP-tagged mutations also facilitate the isolation of specific populations of cells most affected by the targeted mutation. Applying these technologies we are currently investigating the role of Hoxa1 and Hoxa13 in regulating neural crest and mesenchymal patterning in the hindbrain, limb, and urogenital sinus. |
SELECT PUBLICATIONS Knosp WM, Scott V, Bachinger HP, Stadler HS (2004). HOXA13 regulates the expression of bone morphogenetic proteins 2 and 7 to control distal limb morphogenesis. Development Sep;131(18):4581-92. Morgan EA, Nguyen SB, Scott V, and Stadler HS. (2003) Loss of Bmp7 and Fgf8 signaling in Hoxa13-mutant mice causes hypospadia.Development,130(14):3095-109. Stadler HS. (2003) Modelling genitourinary defects in mice: an emerging genetic and developmental system. Nat Rev Genet, 4(6):478-82. Stadler HS, Higgins KM, Capecchi MR (2001). Loss of Eph-receptor expression correlates with loss of cell adhesion and chondrogenic capacity in Hoxa13 mutant limbs. Development 128(21):4177-88. Barrow JR, Stadler HS, Capecchi MR (2000). Roles of Hoxa1 and Hoxa2 in patterning the early hindbrain of the mouse. Development 127,933-944.
For more information on publications, contact the faculty member or search PubMed.
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