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Oregon Health & Science Univ
Molecular & Medical Genetics
Mail Code: L103
3181 SW Sam Jackson
Park Road
Portland, OR 97239
503-494-7703
  Basic Science > Molecular and Medical Genetics > Faculty & Research Interests > Ferguson Research
 
 
Ferguson
Betsy Ferguson, Ph.D. - Research Assistant Professor

Oregon Health & Science University
3181 SW Sam Jackson Park Road
Mail Code L584
Portland, OR  97239

E-Mail:     fergusob@ohsu.edu
 
RESEARCH

The Oregon National Primate Research Center is one of 8 centers in the United States that supports non-human primate breeding and research.  Our lab is committed to developing the genetic tools and resources necessary for the improved understanding of macaques, both in domestic breeding facilities and in international field settings.  The current focus involves the use of single nucleotide polymorphisms (SNPs) for sub-species comparisons and for tracking phenotypes unique to certain populations.  

We also have extensive medical histories of hundreds of captive rhesus macaques available to us. These records, in combination with the large family pedigrees produced within the breeding colonies, allow us to genetically analyze quantitative traits of interest.  Currently we are studying traits commonly found in rhesus macaques, including macular degeneration, resistance to viral diseases, diabetes, as well a variety of behavioral traits. These research efforts involve interactive collaborations with numerous investigators, both at the OHSU and at other universities.
 
SELECT PUBLICATIONS

 

Ferguson, B., Street, S.L., Wright, H., Pearson, C., Jia, Y., Thompson, S.L., Allibone, P., Dubay, C.J., Spindel, E. and R. Norgren.  2007. Single nucleotide polymorphisms (SNPs) distinguish Indian-origin and Chinese-origin rhesus macaques (Macaca mulatta). BMC Genomics 8(1):43.

 

Rhesus Macaque Genome Sequencing and Analysis Consortium. 2007. Evolutionary and biomedical insights from the rhesus macaque genome. Science 316 222-234. Science 316:222-234.

 

R. D. Hernandez, M. J. Hubisz, D. Wheeler, D.G. Smith, B. Ferguson, J. Rogers, L. Nazareth, T.Bourquin, J. McPherson, D. Muzny, R. Gibbs, R. Nielsen, C. D. Bustamante. 2007. Genetic Variation Reveals Diametric Demographic Histories and Patterns of Linkage Disequilibrium for Chinese and Indian Rhesus Macaques.  Science 8:240-3.

 

Street, S., Kyes, R., Grant, R. and Ferguson, B.. 2007. Single nucleotide polymorphisms (SNPs) are highly conserved in rhesus (Macaca mulatta) and cynomolgus (Macaca fascicularis) macaques.  BMC Genomics 8:480.

 

Karl, J.A., Wiseman, R.W., Campbell, J.J., Hughes, A.L., Ferguson, B., Read, D.S, and O’Connor, D.H. 2008. Identification of MHC class I alleles in Chinese-origin rhesus macaques. Immunogenetics 60(1):37-46.

 

Dighe, V., Clepper, L., Pedersen, D., Byrne, J., Ferguson, B., Gokhale, S., Penedo, C., Wolf, D., Mitalipov, S.  2008. Heterozygous stem cells derived from nonhuman primate parthenotes. Stem Cells (Jan 10 epub).

 
For more information on publications, contact the faculty member or search PubMed.

 
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