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Oregon Health & Science Univ
Molecular & Medical Genetics
Mail Code: L103
3181 SW Sam Jackson
Park Road
Portland, OR 97239
503-494-7703

Basic Science > Molecular and Medical Genetics > Faculty & Research Interests > Bagby Research

Grover C. Bagby, M.D. - Professor

Oregon Health & Science University
3181 SW Sam Jackson Park Road
Mail Code CR145
Portland, OR 97239

Office: 503-494-0524
Fax: 503-494-7086

RESEARCH

Acute leukemias are hematopoietic malignancies that derive from single mutant hematopoietic stem cells. It is increasingly evident that the evolution of malignancies of epithelial origin follow these same general rules. The forces that permit the outgrowth of mutant progeny are not well understood. We are seeking to identify such forces using molecular methods. We are focusing on normal cells, cancer cell lines, and cells from children and mice with Fanconi anemia, a rare autosomal recessive disorder characterized by bone marrow failure and subsequent leukemia and epithelial malignancies. We have discovered that mutations in the Fanconi genes impair growth factor signaling and induce programmed cell death in bone marrow progenitor cells and first deduced then proved that subsequent somatic mutations that reduce the rates of programmed cell death are required to initiate the malignant clone either in hematopoietic or epithelial cells. We are seeking to define the signaling defects in detail, and to clarify the somatic mutations that occur in leukemic and cancer stem cells that result in resistance to apoptosis and clonal evolution. undefined

SELECT PUBLICATIONS

Pang, Q, Koretsky, T, Carlson, H, David, L, Keeble, W., Faulkner, G.R., Speckhart, A., Bagby, G.C. Nucleophosmin interacts with and inhibits the catalytic function of eukaryotic initiation factor 2 kinase PKR. J. Biol. Chem.278:41709-41717, 2003

Fagerlie, S., Koretsky, T.,Torok-Storb, B., Bagby, G.C. Impaired type I IFN-induced JAK/Stat signaling in FA-C cells and abnormal CD4+ T-helper cell subsets in Fancc -/-mice. J. Immunol. 173:3863-70, 2004.

Mankad, A., Taniguchi, T., Cox, B., Akkari, Y., Rathbun, R.K., Lucas, L., Bagby, G., Olson, S., D'Andrea, A., Grompe, M. Natural gene therapy in monozygotic twins with Fanconi anemia. Blood 107: 3084-3090, 2005.

Fagerlie, S., Bagby, G.C. Immune Defects in Fanconi Anemia, Critical Rev. Immunol. 26:81-96, 2006

Bagby, G.C., Alter, B.P. Fanconi Anemia, Seminars in Hematology 43:147-156, 2006

For more information on publications, contact the faculty member or search PubMed.

GRADUATE PROGRAM AFFILIATIONS:

PMCB

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