Neurobiology of Disease


  April 10 - Mechanisms of cell death in Parkinson's disease

Gary Westbrook, M.D.

This session will start with a brief overview of proposed causes of the cell death and selective neuronal degeneration that characterizes Parkinson's disease. The review by Moore et al will serve as a background for this part of the discussion. In the second half of the session, we will discuss the paper by Sherer et al. Please come prepared to discuss and present parts of each paper, as this will be an interactive discussion.

Molecular Pathophysiology of Parkinson's Disease [ Download ]
Moore DJ, West AB, Dawson VL, Dawson TM.
Annu Rev Neurosci. 2005;28:57-87..

Chronic systemic pesticide exposure reproduces features of Parkinson's disease [ Download ]
Betarbet R, Sherer TB, MacKenzie G, Garcia-Osuna M, Panov AV, Greenamyre JT.
Nat Neurosci. 2000 Dec;3(12):1301-6