Neurobiology of Disease

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Date:	May 29, 2012 (Tuesday)
Time:	10 a.m.
Theme:	Injury and Repair (Multiple Sclerosis)
Module:	Overview
Session:	Axonal injury and repair
Instructor:	Mary Logan, Jungers Center; Assistant Professor, Neurology
Objectives:	This first part of the session will overview the nervous system response to axonal injury, followed by a student-led discussion of a recent paper.
Study questions:	List Coleman's categories of disruption of axonal transport. What classes of molecules/functions are needed for axons to survive? How long does it take cargo to go from soma to axon terminal in the longest human axons using 'fast' axonal transport?

Readings:	Coleman Adv Genet 73, 185-217, 2011 Avery et al, Curr Biol 22, 596-600, 2012.
Video:	http://www.ohsu.edu/edcomm/flash/flash_player.php?params=1%60/sch/neus/626-052912.flv%60vod&width=640&height=480&title=NEUS%20626%2C%2005/29/12