Neurobiology of Disease


Date: May 1, 2012 (Tuesday)
Time: 10 a.m.
Theme: Neurodegeneration (Alzheimer's, Parkinson's Disease)
Module: Overview
Session: Synuclein and PD
Instructor: Vivek Unni, Assistant Professor, Parkinson Center of Oregon
Objectives: Mutations and overexpression of synuclein have been implicated in some cases of Parkinson's disease. We will discuss synuclein as a presumptive toxic gain-of-function example of neurodegenerative disease.
Study questions:
  1. Is the level of synuclein important in disease pathogenesis?
  2. Are synucleinopathies due to loss-of-function or toxic gain-of-function?
  3. What pathways control synuclein levels in neurons?
  4. Why might secretion of synuclein be important?
  1. Vekrellis et al., Lancet Neurol 10,1015-25, 2011
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  2. Scott et al. J Neurosci, 30, 8083-8095, 2010.
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