Neurobiology of Disease


Date: April 26, 2012 (Thursday)
Time: 10 a.m.
Theme: Neurodegeneration (Alzheimer's, Parkinson's Disease)
Module: Overview
Session: Posing a critical question: Current state of the amyloid hypothesis.
Instructor: Gary Westbrook, Senior Scientist, Vollum Institute; Professor, Neurology, OHSU
Objectives: The amyloid hypothesis has been the dominant focus of research on Alzheimer's disease. We will discuss in a journal club format the current status of this hypothesis. The class will lead the discussion so come prepared.
Study questions:
  1. What is the best evidence for and against the amyloid hypothesis as the causal factor in Alzheimer's disease?
  2. Describe the main steps in processing of APP
  3. What are the "druggable" targets in APP processing?
  4. Assuming one has an effective treatment, at what stage of the disease would you treat and how would you monitor the efficacy of your treatment?
  5. What are the alternatives to the amyloid hypothesis?
  1. Tanzi and Bertram Cell 120, 545-555, 2005
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  2. Morris et al Neuron 70, 410-426, 2011
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