Neurobiology of Disease


Date: April 19, 2012 (Thursday)
Time: 10 a.m.
Theme: Neurodegeneration (Alzheimer's, Parkinson's Disease)
Module: Clinical Demonstration
Session: Patient interview
Instructor: Jay Nutt, Professor, Neurology, OHSU
Objectives: After an overview of the clinical aspects of Parkinson's disease, participants will interview and examine a patient.
Study questions:
  1. What can cause parkinsonism other than the most common "idiopathic" or "sporadic" type?
  2. What are the molecular components of "Lewy" bodies?
  3. What were the first clinical manifestations of PD in this patient?
  4. What aspects of the disease are most disabling for this patient?
  5. Did this patient experience any side effects from treatment for PD?
  1. Nutt and Wooten, N Engl J Med 353, 1021-1027, 2005
    Adobe Acrobat
  2. Wichmann T, DeLong MR (2006). Chapter 46, In Basic Neurochemistry, 7th Ed., (GJ Siegel, RW Albers, ST Brady, DL Price, eds.), Elsevier Academic Press, 761-771.