Neurobiology of Disease

 


 
 
 
Date: June 04, 2010 (Friday)
SPECIAL TIME rescheduled from April 16
Time: 12 noon
Theme: Neurodegeneration (Alzheimer's, Parkinson's Disease and Aging)
Module: Overview
Session: Mechanisms of aging in worms and mice (Andrew Dillin, Salk Institute, Howard Hughes Medical Institute)
Instructor: Andrew Dillin (visiting faculty)
Description: Andrew Dillin from The Salk Institute will discuss his work on aging and neurodegenerative diseases from C.elegans to mice.
Study questions:
  1. Why study diseases in C.elegans?
  2. Can aging be compared in organisms with very different lifespans?
  3. What is the proposed link between IGF-1 signaling, aging and neurodegeneration?
 
Readings:
  1. Cohen E, Paulsson JF, Blinder P, et al (2009) Reduced IGF-1 signaling delays age-associated proteotoxicity in mice. Cell 139:1157-1169.
    Adobe Acrobat
  2. Cohen E, Dillin A (2008) The insulin paradox: aging, proteotoxicity and neurodegeneration. Nat Rev Neurosci 9:759-767.
    Adobe Acrobat
Video: None