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| May 17, 2010 (Monday) |
| 9:00 a.m. - Noon |
| Neuronal-Glial Interactions (Multiple Sclerosis) |
| Overview |
Jungers Center Symposium: Glial-neuronal interactions: implications for neurologic disease.
Jungers Center News & Events |
Klaus-Armin Nave (Max Planck Institute for Experimental Medicine),
Elior Peles (Weizmann Institute),
Will Talbot (Stanford University),
Jonah Chan (University of California, San Francisco) |
| Four invited speakers will present modern approaches to neuro-glial interactions. |
- What are the molecular domains in a myelinated axon in the PNS?
- Talbot has used a forward genetic screen approach to look at myelination.
How did he set up the screen and what are the advantages and limitations? Describe two "hits" in his screen.
- What mechanisms can prevent the differentiation of OPCs into mature oligodendrocytes? Why might this be important?
- What mechanisms does Nave propose as the cause of axonal degeneration after glial damage or loss?
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- Nave KA (2010) Myelination and the trophic support of long axons. Nat Rev Neursoci 11:275-283.
- Chong SY, Chan JR (2010) Tapping into the glial reservoir: cells committed to
remaining uncommitted. J Cell Biol 188:305-312.
- Lyons DA, Naylor SG, Scholze A, Talbot WS (2009) Kif1b is essential for mRNA localization in
oligodendrocytes and development of myelinated axons. Nat Genet 41:854-858.
- Salzer JL, Brophy J, Peles E (2008) Molecular domains of myelinated axons in the peripheral nervous system.
Glia 56:1532-1540.
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