Neurobiology of Disease


Date: May 17, 2010 (Monday)
Time: 9:00 a.m. - Noon
Theme: Neuronal-Glial Interactions (Multiple Sclerosis)
Module: Overview
Session: Jungers Center Symposium: Glial-neuronal interactions: implications for neurologic disease.
Jungers Center News & Events
Instructor: Klaus-Armin Nave (Max Planck Institute for Experimental Medicine),
Elior Peles (Weizmann Institute),
Will Talbot (Stanford University),
Jonah Chan (University of California, San Francisco)
Description: Four invited speakers will present modern approaches to neuro-glial interactions.
Study questions:
  1. What are the molecular domains in a myelinated axon in the PNS?
  2. Talbot has used a forward genetic screen approach to look at myelination. How did he set up the screen and what are the advantages and limitations? Describe two "hits" in his screen.
  3. What mechanisms can prevent the differentiation of OPCs into mature oligodendrocytes? Why might this be important?
  4. What mechanisms does Nave propose as the cause of axonal degeneration after glial damage or loss?
  1. Nave KA (2010) Myelination and the trophic support of long axons. Nat Rev Neursoci 11:275-283.
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  2. Chong SY, Chan JR (2010) Tapping into the glial reservoir: cells committed to remaining uncommitted. J Cell Biol 188:305-312.
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  3. Lyons DA, Naylor SG, Scholze A, Talbot WS (2009) Kif1b is essential for mRNA localization in oligodendrocytes and development of myelinated axons. Nat Genet 41:854-858.
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  4. Salzer JL, Brophy J, Peles E (2008) Molecular domains of myelinated axons in the peripheral nervous system. Glia 56:1532-1540.
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Video: None