Neurobiology of Disease


Date: April 26, 2010 (Monday)
Time: 10:30 a.m.
Theme: Bypassing Repair - Neural Prostheses
Module: Overview
Session: Posing a critical question: Is it easier to replace rather than repair the nervous system?
Instructor: Gary Westbrook
Description: This journal club session will discuss papers from the two speakers in the April 27 mini-symposium on Neural Prosthetics.
Study questions:
  1. What treatment options are available for patients with photoreceptor degenerations (RP and AMD)?
  2. What is the evidence that the Humayun 16-electrode device works as imagined?
  3. What are the problems associated with making larger grids for the retinal implants?
  4. In the Moritz paper, what do they mean by an "arbitrary" motor cortex cell?
  5. What are the advantages of single neurons vs. neuronal ensembles for cortical control of muscles in the Moritz experiments?
  1. Moritz CT, Perlmutter SI, Fetz EE (2008) Direct control of paralysed muscles by cortical neurons. Nature 456:639-642.
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  2. Chader GJ, Weiland J, Humayun MS (2009) Artificial vision: needs, functioning, and testing of a retinal electronic prosthesis. Prog Brain Res 175:317-332.
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  3. Caspi A, Dorn JD, McClure KH, et al (2009) Feasibility study of a retinal prosthesis: spatial vision with a 16-electrode implant. Arch Ophthalmol 127:398-401.
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