Neurobiology of Disease

 


 
 
 
Date: April 14, 2010 (Wednesday)
Time: 10:30 a.m.
Theme: Neurodegeneration (Alzheimer's, Parkinson's Disease and Aging)
Module: Overview
Session: The nervous system in healthy and unhealthy aging.
Instructor: Jacob Raber
Description: This session will overview the changes in the nervous system that accompany aging and highlight some of the work from the presenter's work on hormone effects on aging.
Study questions:
  1. What are the cognitive changes and changes in neuronal markers that occur during healthy aging?
  2. Are there sex differences in age-related cognitive decline and changes in these markers?
  3. Are specific brain areas particularly vulnerable to age-related changes?
  4. What brain areas might be particularly responsive to hormone treatments in aged animals?
 
Readings:
  1. Benice TS, Raber J (2009) Testosterone and dihydrotestosterone differentially improve cognition in aged female mice. Learn Mem 16:479-485.
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  2. Buckner RL (2004) Memory and executive function in aging and AD: multiple factors that cuase decline and reserve factors that compensate. Neuron 44:195-208.
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Video:
  1. http://www.ohsu.edu/edcomm/flash/flash_player.php?params=4%60/sch/neus/626-041410.flv%60vod&width=640&height=480&title=NEUS%20626%20%204-14-2010