Neurobiology of Disease

 


 
 
 
Date: April 9, 2010 (Friday)
Time: 10:30 a.m.
Theme: Neurodegeneration (Alzheimer's, Parkinson's Disease and Aging)
Module: Overview
Session: Posing a critical question: Designing treatments for neurodegenerative diseases.
Instructor: Gary Westbrook
Description: This session will overview the general strategies to treatments for neurodegenerative disease, using Alzheimer's as the principal example.
Study questions:
  1. Assuming one has an effective treatment, at what stage of the disease would you treat?
  2. Assuming the amyloid hypothesis is correct in Alzheimer's disease, discuss several general ways to prevent amyloid deposition.
  3. How would you monitor the efficacy of your treatment?
  4. Be prepared to discuss the parts of the papers assigned that have to do with therapeutic approaches.
 
Readings:
  1. Brody DL, Holtzman DM (2008) Active and passive immunotherapy for neurodegenerative disorders. Annu Rev Neurosci 31:175-193.
    Adobe Acrobat
  2. Bergmans BA, De Strooper B (2010) gamma-secretases: from cell biology to therapeutic strategies. Lancet 9:215-226.
    Adobe Acrobat
Video:
  1. http://www.ohsu.edu/edcomm/flash/flash_player.php?params=4%60/sch/neus/626-040910.flv%60vod&width=640&height=480&title=NEUS%20626%2C%20April%209%2C%202010