April 7, 2010 (Wednesday)
Neurodegeneration (Alzheimer's, Parkinson's Disease and Aging)
Posing a critical question: The status of amyloid hypothesis
Joe Quinn/Doris Kretzschmar
The amyloid hypothesis has been the dominant focus of research on Alzheimer's disease. We will discuss the current status of this hypothesis. The class will lead the discussion so come prepared.
What is the best evidence for and against the amyloid hypothesis as the causal factor in Alzheimer's disease?
Describe the main steps in processing of APP.
What are the "druggable" targets in APP processing?
Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297:353-356.
Tanzi RE, Bertram L (2005) Twenty years of the Alzheimer's disease amyloid hypothesisL a genetic perspective. Cell 120:545-555.
Last modified on 06/01/2010 by