Neurobiology of Disease


Date: April 7, 2010 (Wednesday)
Time: 10:30 a.m.
Theme: Neurodegeneration (Alzheimer's, Parkinson's Disease and Aging)
Module: Overview
Session: Posing a critical question: The status of amyloid hypothesis
Instructor: Joe Quinn/Doris Kretzschmar
Description: The amyloid hypothesis has been the dominant focus of research on Alzheimer's disease. We will discuss the current status of this hypothesis. The class will lead the discussion so come prepared.
Study questions:
  1. What is the best evidence for and against the amyloid hypothesis as the causal factor in Alzheimer's disease?
  2. Describe the main steps in processing of APP.
  3. What are the "druggable" targets in APP processing?
  1. Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297:353-356.
    Adobe Acrobat
  2. Tanzi RE, Bertram L (2005) Twenty years of the Alzheimer's disease amyloid hypothesisL a genetic perspective. Cell 120:545-555.
    Adobe Acrobat