Neurobiology of Disease

 


 
 
 
Date: May 29, 2009 (Friday)
Time: 10:30 a.m.
Theme: Dopamine systems - movement and reward (PD and substance abuse)
Module: Overview
Session: Maladaptive plasticity and addiction
Instructor: John Williams
Description: This session will discuss the maladaptive changes in the normal reward pathways that contribute to addiction and substance abuse.
Study questions:
  1. Is dopamine addictive?
  2. Why might exogenous dopamine be more active on limbic pathways than motor pathways in Parkinson's disease?
  3. Is dopamine an absolute requirement for all reward learning?
 
Readings:
  1. Dagher A, Robbins TW (2009). Personality, addiction, dopamine: insights from Parkinson's disease. Neuron 61:502-508.
    Adobe Acrobat
  2. Kreitzer AC, Malenka RC (2008). Striatal plasticity and basal ganglia circuit function. Neuron 60:543-554. (optional)
    Adobe Acrobat
Video: