Neurobiology of Disease


Date: May 29, 2009 (Friday)
Time: 10:30 a.m.
Theme: Dopamine systems - movement and reward (PD and substance abuse)
Module: Overview
Session: Maladaptive plasticity and addiction
Instructor: John Williams
Description: This session will discuss the maladaptive changes in the normal reward pathways that contribute to addiction and substance abuse.
Study questions:
  1. Is dopamine addictive?
  2. Why might exogenous dopamine be more active on limbic pathways than motor pathways in Parkinson's disease?
  3. Is dopamine an absolute requirement for all reward learning?
  1. Dagher A, Robbins TW (2009). Personality, addiction, dopamine: insights from Parkinson's disease. Neuron 61:502-508.
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  2. Kreitzer AC, Malenka RC (2008). Striatal plasticity and basal ganglia circuit function. Neuron 60:543-554. (optional)
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