Neurobiology of Disease


Date: May 26, 2009 (Tuesday)
Time: 2 p.m.
Theme: Dopamine systems - movement and reward (PD and substance abuse)
Module: Overview
Session: Basal ganglia function in health and Parkinsonís disease.
Instructor: Charles Wilson (Visiting faculty)
Description: Charles Wilson, a computational neuroscientist and expert on the basal ganglia, will discuss the normal function of the basal ganglia, how it is altered by Parkinson's disease, and how it is affected by treatments such as deep brain stimulation.
Study questions:
  1. Diagram or describe the direct and indirect pathways in the basal ganglia.
  2. Does striatal dopamine influence these two pathways in the same manner?
  3. What is the potential relevance of oscillatory firing in subthalamic nucleus and external globus pallidus neurons to dysfunction in Parkinson's disease?
  1. Bevan MD, Magill PJ, Terman D, Bolam JP, Wilson CJ (2002). Move to the rhythm: oscillations in the subthalamic nucleus-external globus pallidus network. TINS 25:525-531.
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  2. Delong MR, Wichmann T (2007). Circuits and circuit disorders of the basal ganglia. Arch Neurol 64:20-24.
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