Neurobiology of Disease

 


 
 
 
Date: May 20, 2009 (Wednesday)
Time: 10:30 a.m.
Theme: Dopamine systems - movement and reward (PD and substance abuse)
Module: ToolBox
Session: Clinical Trials
Instructor: Penny Hogarth
Description: This session will provide a practical introduction to how clinical trials are designed, staged (Phase 1-3, etc) and conducted.
Study questions:
  1. Describe the purpose of randomization and the use of "double-blind controls.
  2. What's the advantage of a cross-over trial design?
  3. Describe some of the factors in selecting the best "outcome variable" for a clinical trial.
 
Readings:
  1. Marshall FJ, Kieburtz K, McDermott M, Kurlan R, Shoulson I (1996). Clinical research in neurology: from observation to experimentation. Neurologic Clinics 14:451-466.
    Adobe Acrobat
Video:
  1. http://media/ohsu.edu/ramgen/sch/ogi/neus/626-052009.rm