Neurobiology of Disease

 


 
 
 
Date: May 11, 2009 (Monday)
Time: 10:30 a.m.
Theme: Axonal Degeneration (Multiple Sclerosis)
Module: ToolBox
Session: EAE as a model of MS
Instructor: Dennis Bourdette/Arthur Vandenbark
Description: This session will present a brief overview of the history of EAE as model, evolving out of studies on post-rabies vaccination encephalomyelitis, and then discuss the strengths and weaknesses of murine EAE models for studying mechanism of action and developing treatment approaches for MS, particularly with regards to axonal degeneration.
Study questions:
  1. What is the main argument by Sriram and Steiner agains the use of EAE?
  2. Does an animal model need to replicate exactly the human disease to be useful?
  3. How does one avoid the trap of studying EAE, rather than using it as an animal model?
 
Readings:
  1. Sriram S, Steiner I (2005). Experimental allergic encephalomyelitis: a misleading model of multiple sclerosis. Ann Neurol 58:939-945.
    Adobe Acrobat
  2. Steinman L, Zamvil SS (2006). How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis. Ann Neurol 60:12-21.
    Adobe Acrobat
Video:
  1. http://media.ohsu.edu/ramgen/sch/ogi/neus/626-051109.rm