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| May 11, 2009 (Monday) |
| 10:30 a.m. |
| Axonal Degeneration (Multiple Sclerosis) |
| ToolBox |
| EAE as a model of MS |
| Dennis Bourdette/Arthur Vandenbark |
| This session will present a brief overview of the history of EAE as model, evolving out of
studies on post-rabies vaccination encephalomyelitis, and then discuss the strengths and weaknesses
of murine EAE models for studying mechanism of action and developing treatment approaches for MS,
particularly with regards to axonal degeneration. |
- What is the main argument by Sriram and Steiner agains the use of EAE?
- Does an animal model need to replicate exactly the human disease to be useful?
- How does one avoid the trap of studying EAE, rather than using it as an animal model?
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- Sriram S, Steiner I (2005). Experimental allergic encephalomyelitis: a misleading model of
multiple sclerosis. Ann Neurol 58:939-945.
- Steinman L, Zamvil SS (2006). How to successfully apply animal studies in experimental
allergic encephalomyelitis to research on multiple sclerosis. Ann Neurol 60:12-21.
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- http://media.ohsu.edu/ramgen/sch/ogi/neus/626-051109.rm
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