Neurobiology of Disease


Date: May 8, 2009 (Friday)
Time: 10:30 a.m.
Theme: Axonal Degeneration (Multiple Sclerosis)
Module: Overview
Session: Posing a critical question: early triggers and preclinical diagnosis
Instructor: Gary Westbrook/Ruth Whitman
Description: With the development of therapies that reduce relapses in MS, the need for early diagnosis and an understanding of the early triggers in MS become even more critical. This session will explore this topic by discussing several recent papers in a journal club format.
Study questions:
  1. How has MRI helped make a diagnosis of MS in "clinically isolated syndrome"?
  2. What is the "radiologically isolated syndrome" as defined by Okuda et al.?
  3. What are the risks and benefits of treating an asymptomatic patient?
  1. Tintore M (2008). Rationale for early intervention with immunomodulatory treatment. J Neurol 255 [Suppl 1]:37-43.
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  2. Okuda DT, Mowry EM, Beheshtian A, Waubant E, Baranzini SE, Goodin DS, Hauser SL, Pelletier D (2009) Incidental MRI anomalies suggestive of multiple sclerosis. Neurology 72:800-805.
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