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| May 1, 2009 (Friday) |
| 10:30 a.m. |
| Sensory Failure (Hearing loss) |
| Overview |
| Posing a critical question: Deafness genes and molecules |
| Teresa Nicolson |
| There has been a rapid increase in the identification of genes involved in normal hearing as
well as mutant genes involved in hereditary hearing loss. Following a short introduction to set the
context, we will discuss two recent articles in a journal club format. |
- Draw an annotated cartoon of a hair cell and identify at least 5 sites at which
mutations in molecules might lead to deafness.
- How might miRNA96 (Mencia et al and Lewis et al) lead to hearing loss?
- How do microRNAs affect gene expression?
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- Gillespie PG (2006). Molecular biology of hearing and balance. In Basic Neurochemistry, 7th Ed.,
(GJ Siegel, RW Albers, ST Brady, DL Price, eds.), Elsevier Academic Press, 833-840.
- Mencia A, Modamio-Hoybjor S, Redshaw N, Morin M, Mayo-Merino F, Olavarrieta L, Aguirre LA, del
Castillo I, Steel KP, Dalmay T, Moreno F, Moreno-Pelayo MA (2009). Mutations in the seed region of
human miR-96 are responsible for nonsyndromic progressive hearing loss. Nat Genet 41:609-613.
- Lewis MA, Quint E, Glazier AM, Fuchs H, De Angelis MH, Langford C, van Dongen S, Abreu-Goodger
C, Piipari M, Redshaw N, Dalmay T, Moreno-Pelayo MA, Enright AJ, Steel KP. (2009). An ENU-induced
mutation of miR-96 associated with progressive hearing loss in mice. Nat Genet 41:614-618
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- http://media.ohsu.edu/ramgen/sch/ogi/neus/626-050109.rm
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