Neurobiology of Disease

 


 
 
 
Date: April 24, 2009 (Friday)
Time: 10:30 a.m.
Theme: Neurodegeneration (ALS and Alzheimer's)
Module: Overview
Session: Abeta and tau in the pathogenesis of Alzheimer's disease: whether, when and how to treat.
Instructor: David Holtzman (visiting faculty)
Description: David Holtzman, an expert on Alzheimer's disease will provide us with an update on treatment strategies for Alzheimer's.
Study questions:
  1. If there was an effective immunotherapy for Alzheimer's, at what stage of the disease would you want to treat?
  2. If your answer to #1 is early, what special problems does that create?
  3. How dependent is the success of immunotherapy on knowing the mechanism of action of the target, e.g. Abeta or tau?
 
Readings:
  1. Brody DL, Holtzman DM (2008). Active and passive immunotherapy for neurodegenerative disorders. Annu Rev Neurosci 31:175-193.
    Adobe Acrobat
Video:
  1. http://media/ohsu.edu/ramgen/sch/ogi/neus/626-042409.rm