Neurobiology of Disease


Date: April 24, 2009 (Friday)
Time: 10:30 a.m.
Theme: Neurodegeneration (ALS and Alzheimer's)
Module: Overview
Session: Abeta and tau in the pathogenesis of Alzheimer's disease: whether, when and how to treat.
Instructor: David Holtzman (visiting faculty)
Description: David Holtzman, an expert on Alzheimer's disease will provide us with an update on treatment strategies for Alzheimer's.
Study questions:
  1. If there was an effective immunotherapy for Alzheimer's, at what stage of the disease would you want to treat?
  2. If your answer to #1 is early, what special problems does that create?
  3. How dependent is the success of immunotherapy on knowing the mechanism of action of the target, e.g. Abeta or tau?
  1. Brody DL, Holtzman DM (2008). Active and passive immunotherapy for neurodegenerative disorders. Annu Rev Neurosci 31:175-193.
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