| April 22, 2009 (Wednesday) |
| 10:30 a.m. |
| Neurodegeneration (ALS and Alzheimer's) |
| Overview |
| Posing a critical question: the status of the amyloid hypothesis. |
| Joe Quinn/Doris Kretzschmar |
| The amyloid hypothesis has been the dominant focus of research on Alzheimer's disease.
We will discuss the current status of this hypothesis. |
- Describe the main steps in processing of APP.
- What are the "druggable" targets in APP processing?
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| |
- Hardy J, Selkoe DJ (2002). The amyloid hypothesis of Alzheimer's disease: progress and problems on the
road to therapeutics. Science 297: 353-356.
- Tanzi RE, Bertram L (2005). Twenty years of the Alzheimer's disease amyloid hypothesis:
a genetic perspective. Cell 120:545-555.
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- http://media.ohsu.edu/ramgen/sch/ogi/neus/626-042209.rm
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