Neurobiology of Disease


Date: April 22, 2009 (Wednesday)
Time: 10:30 a.m.
Theme: Neurodegeneration (ALS and Alzheimer's)
Module: Overview
Session: Posing a critical question: the status of the amyloid hypothesis.
Instructor: Joe Quinn/Doris Kretzschmar
Description: The amyloid hypothesis has been the dominant focus of research on Alzheimer's disease. We will discuss the current status of this hypothesis.
Study questions:
  1. Describe the main steps in processing of APP.
  2. What are the "druggable" targets in APP processing?
  1. Hardy J, Selkoe DJ (2002). The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297: 353-356.
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  2. Tanzi RE, Bertram L (2005). Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective. Cell 120:545-555.
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