Neurobiology of Disease

 


 
 
 
Date: April 20, 2009 (Monday)
Time: 10:30 a.m.
Theme: Neurodegeneration (ALS and Alzheimer's)
Module: ToolBox
Session: Animal models of neurodegenerative diseases.
Instructor: Doris Kretzschmar
Description: This session will explore the value of animal models in the study of neurodegenerative diseases.
Study questions:
  1. Discuss the relative merits of different animals models in studies of neurodegeneration (e.g. C. elegans, zebrafish, drosophila, mouse, dog, primate)
 
Readings:
  1. Hariharan IK, Haber DA (2003). Yeast, flies, worms, and fish in the study of human disease. N Engl J Med 348:2457-2463.
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  2. Gotz J, Ittner LM (2008). Animal models of Alzheimer's disease and frontotemporal dementia. Nat Rev Neurosci 9:532-544.
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Video:
  1. http://media.ohsu.edu/ramgen/sch/ogi/neus/042009.rm