Neurobiology of Disease


Date: April 15, 2009 (Wednesday)
Time: 10:30 a.m.
Theme: Neurodegeneration (ALS and Alzheimer's)
Module: Overview
Session: Astrocytes, oxidative stress and neurodegeneration
Instructor: Joe Beckman (visiting faculty)
Description: This session will explore the role of astrocytes and oxidative injury in neurodegeneration and consider the specific issue of SOD and ALS.
Study questions:
  1. How are oxidants produced in neurons and glia?
  2. What natural mechanisms limit the general of free radicals?
  3. Discuss the mechanisms by which SOD1 mutations are thought to cause ALS.
  1. Ischiropoulos H, Beckman JS (2003). Oxidative stress and nitration in neurodegeneration: Cause, effect, or association? J Clin Invest 111:163-169.
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  2. Rothstein JD (2009). Current hypotheses for the underlying biology of amyotrophic lateral sclerosis. Ann Neurol 65 [suppl]:S3-S9.
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