Neurobiology of Disease


Date: April 8, 2009 (Wednesday)
Time: 10:30 a.m.
Theme: Neurodegeneration (ALS and Alzheimer's)
Module: Overview
Session: Posing critical questions: selective vulnerability
Instructor: Joe Quinn/Gary Westbrook
Description: Motor neuron diseases epitomize the selective degeneration of a population of neurons. We will discuss how that might happen and whether "selective vulnerability" provides clues to the underlying mechanisms of neurodegeneration in general.
Study questions:
  1. What does 'selective vulnerability' mean?
  2. Is it selective?
  3. Give three examples of neurodegenerative diseases and the neuronal groups that are selectively vulnerable in each.
  4. List 3 mechanisms that might, or have been proposed to, explain the selective vulnerabilty in each of the 3 diseases.
  1. Shaw PJ, Eggett CJ (2000). Molecular factors underlying selective vulnerability of motor neurons to neurodegeneration in amyotrophic lateral sclerosis. J Neurol 247 [Suppl 1]: I/17-I/27.
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  2. Hardy J, Gwinn-Hardy K (1998). Genetic classification of primary neurodegenerative disease. Science 282:1075-1079.
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