| April 8, 2009 (Wednesday) |
| 10:30 a.m. |
| Neurodegeneration (ALS and Alzheimer's) |
| Overview |
| Posing critical questions: selective vulnerability |
| Joe Quinn/Gary Westbrook |
| Motor neuron diseases epitomize the selective degeneration of a population of neurons.
We will discuss how that might happen and whether "selective vulnerability" provides clues
to the underlying mechanisms of neurodegeneration in general. |
- What does 'selective vulnerability' mean?
- Is it selective?
- Give three examples of neurodegenerative diseases and the neuronal groups that are selectively vulnerable in each.
- List 3 mechanisms that might, or have been proposed to, explain the selective vulnerabilty in each of the 3 diseases.
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| |
- Shaw PJ, Eggett CJ (2000). Molecular factors underlying selective vulnerability of
motor neurons to neurodegeneration in amyotrophic lateral sclerosis. J Neurol 247 [Suppl 1]: I/17-I/27.
- Hardy J, Gwinn-Hardy K (1998). Genetic classification of primary neurodegenerative disease.
Science 282:1075-1079.
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