Neurobiology of Disease

 


 
 
 
Date: May 28, 2008 (Wednesday)
Time: 10 a.m.
Theme: Synaptic function and dysfunction in the peripheral nervous system
Module: Overview
Session: Autonomic neurotransmission in the heart
Instructor: Habecker
Description: Neurotransmission in the autonomic nervous system differs in some ways from the neuromuscular junction, e.g. in the importance of “volume” transmission, the spectrum of receptors and the variety of co-transmitters. This session will briefly overview autonomic transmission and discuss polymorphisms in adrenergic receptors that alter the response to norepinephrine and modulate the risk for cardiac disease.
 
Readings:
  1. Esler et al. Sympathetic nerve activity and neurotransmitter release in humans: translation from pathophysiology into clinical practive. Acta Physiol Scand 177,275-284, 2003
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  2. Small et al., Synergistic polymorphisms of b1 and a2c-adrenergic receptors and the risk of congestive heart failure. New Engl J Med 347, 1135-1142, 2002.
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Supplemental Background
  1. Goldstein et al., Dysautonomias: Clinical disorders of the autonomic nervous system. Ann Intern Med 137,753-763, 2002.
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Video:
  1. 052808 NEUS 626: http://media.ohsu.edu/ramgen/sch/ogi/neus/626-052808.rm