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| May 28, 2008 (Wednesday) |
| 10 a.m. |
| Synaptic function and dysfunction
in the peripheral nervous system |
| Overview |
| Autonomic neurotransmission in the heart |
| Habecker |
| Neurotransmission in the autonomic nervous system differs in some ways from
the neuromuscular junction, e.g. in the importance of “volume” transmission, the
spectrum of receptors and the variety of co-transmitters. This session will briefly
overview autonomic transmission and discuss polymorphisms in adrenergic receptors
that alter the response to norepinephrine and modulate the risk for cardiac disease. |
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- Esler et al. Sympathetic nerve activity and neurotransmitter release in
humans: translation from pathophysiology into clinical practive. Acta Physiol
Scand 177,275-284, 2003

- Small et al., Synergistic polymorphisms of b1 and a2c-adrenergic receptors
and the risk of congestive heart failure. New Engl J Med 347, 1135-1142, 2002.
Supplemental Background
- Goldstein et al., Dysautonomias: Clinical disorders of the autonomic nervous system.
Ann Intern Med 137,753-763, 2002.
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- 052808 NEUS 626: http://media.ohsu.edu/ramgen/sch/ogi/neus/626-052808.rm
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