Neurobiology of Disease


Date: May 28, 2008 (Wednesday)
Time: 10 a.m.
Theme: Synaptic function and dysfunction in the peripheral nervous system
Module: Overview
Session: Autonomic neurotransmission in the heart
Instructor: Habecker
Description: Neurotransmission in the autonomic nervous system differs in some ways from the neuromuscular junction, e.g. in the importance of “volume” transmission, the spectrum of receptors and the variety of co-transmitters. This session will briefly overview autonomic transmission and discuss polymorphisms in adrenergic receptors that alter the response to norepinephrine and modulate the risk for cardiac disease.
  1. Esler et al. Sympathetic nerve activity and neurotransmitter release in humans: translation from pathophysiology into clinical practive. Acta Physiol Scand 177,275-284, 2003
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  2. Small et al., Synergistic polymorphisms of b1 and a2c-adrenergic receptors and the risk of congestive heart failure. New Engl J Med 347, 1135-1142, 2002.
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Supplemental Background
  1. Goldstein et al., Dysautonomias: Clinical disorders of the autonomic nervous system. Ann Intern Med 137,753-763, 2002.
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