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| May 12, 2008 (Monday) |
| 10 a.m. |
| Ischemia and stroke |
| Overview |
| Neuroprotection and preconditioning |
| Stenzel-Poore |
| Following ischemia, not all affected tissue is inevitably destined to die.
One of the most explored areas of investigation in experimental stroke has
been "neuroprotection", the idea that taking some measures could prevent death of
neurons and brain tissue. Subseqently, it was realized that some stimuli delivered
prior to ischemia could also modify the effect of the ischemia,
so-called "preconditioning". This session will explore the basis of these
effects and how they may relate to stroke treatment. |
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- Gidday JM (2006). Cerebral preconditioning and ischaemic tolerance.
Nat Rev Neurosci 7, 437-448.
- Stenzel-Poore MP et al. (2003). Effect of ischaemic preconditioning on genomic
response to cerebral ischaemia: similarity to neuroprotective strategies in
hibernation and hypoxia-tolerant states. Lancet 362, 1028-1037.
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- 051208 NEUS 626: http://media.ohsu.edu/ramgen/sch/ogi/neus/626-051208.rm
- 051208 NEUS 627: http://media.ohsu.edu/ramgen/sch/ogi/neus/627-051208.rm
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