Neurobiology of Disease


Date: May 12, 2008 (Monday)
Time: 10 a.m.
Theme: Ischemia and stroke
Module: Overview
Session: Neuroprotection and preconditioning
Instructor: Stenzel-Poore
Description: Following ischemia, not all affected tissue is inevitably destined to die. One of the most explored areas of investigation in experimental stroke has been "neuroprotection", the idea that taking some measures could prevent death of neurons and brain tissue. Subseqently, it was realized that some stimuli delivered prior to ischemia could also modify the effect of the ischemia, so-called "preconditioning". This session will explore the basis of these effects and how they may relate to stroke treatment.
  1. Gidday JM (2006). Cerebral preconditioning and ischaemic tolerance. Nat Rev Neurosci 7, 437-448.
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  2. Stenzel-Poore MP et al. (2003). Effect of ischaemic preconditioning on genomic response to cerebral ischaemia: similarity to neuroprotective strategies in hibernation and hypoxia-tolerant states. Lancet 362, 1028-1037.
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