Neurobiology of Disease


Date: April 30, 2008 (Wednesday)
Time: 10 a.m.
Theme: Regeneration and repair: brain and spinal cord trauma
Module: ToolBox
Session: Diffusion Tensor Imaging
Instructor: Kroenke
Description: Traumatic injuries to the nervous system can be focal and obvious, or more diffuse and inobvious. The distinction between mild traumatic brain injury and post-traumatic stress disorder in soldiers returning from Iraq provides a recent example where diagnostic distinctions can be difficult. In order to assess clinical management and research initiatives, it is critical to be able to assess the type and extent of injury. Diffusion tensor imaging (DTI) has shown promise in the assessment of diffuse axonal injury following trauma. This imaging method will be highlighted in this session.
  1. Mori S and Zhang J (2006). Principles of diffusion tensor imaging and its applications in basic neuroscience research. Neuron 51,527-539.
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Background readings:
  1. MacDonald CL et al (2007). Detection of traumatic axonal injury with diffusion tensor imaging in a mouse model of traumatic brain injury. Exper Neurol 205,116-131.
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  1. 043008 NEUS 626: